Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma

Stephen B. Baylin; Donald S. Gann; Susan H. Hsu

doi:10.1126/science.935869

Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma

Stephen B. Baylin, Donald S. Gann, Susan H. Hsu

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Abstract

A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.

Original language	English (US)
Pages (from-to)	321-323
Number of pages	3
Journal	Science
Volume	193
Issue number	4250
DOIs	https://doi.org/10.1126/science.935869
State	Published - 1976
Externally published	Yes

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title = "Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma",

abstract = "A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.",

author = "Baylin, {Stephen B.} and Gann, {Donald S.} and Hsu, {Susan H.}",

year = "1976",

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AU - Baylin, Stephen B.

AU - Gann, Donald S.

AU - Hsu, Susan H.

PY - 1976

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N2 - A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.

AB - A black female with inherited medullary thyroid carcinoma and pheochromocytoma was a mosaic for glucose-6-phosphate dehydrogenase types A and B in normal tissues (blood, thyroid, and adrenal gland); both the medullary carcinoma and pheochromocytoma tissue showed a B pattern only. This finding suggests a single clone origin for each of the tumors. Other inherited tumors similarly studied in man have appeared to be multiclonal in origin.

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Clonal origin of inherited medullary thyroid carcinoma and pheochromocytoma

Abstract

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