TY - JOUR
T1 - Clonal Hematopoiesis of Indeterminate Potential in Patients with Solid Tumor Malignancies
AU - Marshall, Catherine H.
AU - Gondek, Lukasz P.
AU - Luo, Jun
AU - Antonarakis, Emmanuel S.
N1 - Publisher Copyright:
© 2022 American Association for Cancer Research.
PY - 2022/11/15
Y1 - 2022/11/15
N2 - Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of cells of hematopoietic lineage that carry acquired somatic alterations associated with hematologic malignancies. The most commonly altered genes giving rise to CHIP are DNMT3A, TET2, and ASXL1. However, advanced sequencing technologies have resulted in highly sensitive detection of clonal hematopoiesis beyond these known driver genes. In practice, CHIP is commonly identified as an incidental finding in liquid and tissue biopsies of patients with solid tumors. CHIP can have broad clinical consequences, given its association with hematologic malignancies and nonmalignant diseases. CHIP can also interfere with next-generation DNA sequencing results, so clinicians should pay careful attention when these results are being used to guide therapy. Future research is needed to determine how solid tumor malignancies and their treatments alter the progression of CHIP, and in turn, how CHIP might be used to improve treatment selection and outcomes for patients with solid tumors.
AB - Clonal hematopoiesis of indeterminate potential (CHIP) refers to the expansion of cells of hematopoietic lineage that carry acquired somatic alterations associated with hematologic malignancies. The most commonly altered genes giving rise to CHIP are DNMT3A, TET2, and ASXL1. However, advanced sequencing technologies have resulted in highly sensitive detection of clonal hematopoiesis beyond these known driver genes. In practice, CHIP is commonly identified as an incidental finding in liquid and tissue biopsies of patients with solid tumors. CHIP can have broad clinical consequences, given its association with hematologic malignancies and nonmalignant diseases. CHIP can also interfere with next-generation DNA sequencing results, so clinicians should pay careful attention when these results are being used to guide therapy. Future research is needed to determine how solid tumor malignancies and their treatments alter the progression of CHIP, and in turn, how CHIP might be used to improve treatment selection and outcomes for patients with solid tumors.
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U2 - 10.1158/0008-5472.CAN-22-0985
DO - 10.1158/0008-5472.CAN-22-0985
M3 - Review article
C2 - 36040522
AN - SCOPUS:85141934533
SN - 0008-5472
VL - 82
SP - 4107
EP - 4113
JO - Cancer Research
JF - Cancer Research
IS - 22
ER -