TY - JOUR
T1 - Clonal chromosomal abnormalities in Fanconi's anaemia
T2 - What do they really mean?
AU - Alter, B. P.
AU - Scalise, A.
AU - McCombs, J.
AU - Najfeld, V.
PY - 1993
Y1 - 1993
N2 - Patients with Fanconi's anaemia (FA) have aplastic anaemia, leukaemia, myelodysplasia and tumours. Since leukaemia has a very poor prognosis, it is desirable to identify high-risk patients. To determine the significance of clonal marrow chromosomal abnormalities we began a prospective study in 17 patients: five were normal, eight aplastic, and four myelodysplastic. Three of 11 with adequate cytogenetics had transient abnormal clones. None had leukaemia at 3-24 months. Changing cytogenetic patterns may not be related to leukaemic evolution in patients with a DNA repair defect.
AB - Patients with Fanconi's anaemia (FA) have aplastic anaemia, leukaemia, myelodysplasia and tumours. Since leukaemia has a very poor prognosis, it is desirable to identify high-risk patients. To determine the significance of clonal marrow chromosomal abnormalities we began a prospective study in 17 patients: five were normal, eight aplastic, and four myelodysplastic. Three of 11 with adequate cytogenetics had transient abnormal clones. None had leukaemia at 3-24 months. Changing cytogenetic patterns may not be related to leukaemic evolution in patients with a DNA repair defect.
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M3 - Article
C2 - 8136289
AN - SCOPUS:0027507581
SN - 0007-1048
VL - 85
SP - 627
EP - 630
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 3
ER -