Clinicopathological Features of 19 Eyelid Pilomatrixomas

Sepideh Siadati, Ashley A. Campbell, Timothy McCulley, Charles G. Eberhart

Research output: Contribution to journalArticlepeer-review


Introduction: Pilomatrixoma is a relatively rare, benign tumor arising from the hair root matrix. It is found frequently on the head and neck, with most involving the eyebrow in the periocular region. In contrast, eyelid pilomatrixoma is less common, and often clinically misdiagnosed. Here, we present clinical and histological data from 19 pilomatrixomas arising in the eyelid. Methods: The study represents a retrospective study of eyelid pilomatrixoma diagnosed at our institution since 1981. All slides were reviewed, and demographic as well as clinical data were obtained. Results: Patient ages ranged from 2 to 63 years (mean 24 years), including 12 (63%) females and 7 (37%) males. Eight (42%) and 4 (21%) cases arose in the first and second decades of life, respectively. Upper eyelid involvement was found in 14 (74%) of cases. Microscopically, the tumors were characterized by basaloid and shadow cells accompanied by calcification and foreign body giant cells. Conclusions: Eyelid pilomatrixoma is rarely suspected clinically, and can be mistaken for cyst, chalazion, sebaceous carcinoma, and other tumors. Physicians should consider the possibility of pilomatrixoma in the eyelid area, especially in children or young female patients. Complete excision is curative, and diagnosis can generally be established by histopathological examination.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalOcular Oncology and Pathology
Issue number1
StatePublished - Feb 1 2022


  • Adnexal tumor
  • Eyelid
  • Pilomatrixoma

ASJC Scopus subject areas

  • General Nursing


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