Clinicopathological features and surgical outcomes of resected functional pancreatic neuroendocrine tumors: A single institution experience

Ammar A. Javed, Alina Hasanain, Aleezay Haider, George Jones, Zunaira N. Javed, Kevin Soares, Richard A. Burkhart, John L. Cameron, Matthew J Weiss, Christopher L. Wolfgang, Jin He

Research output: Contribution to journalArticlepeer-review


Background:Functional pancreatic neuroendocrine tumors (f-PanNETs) are rare tumors of the pancreas that are associated with excess hormone production. A majority of literature available on these tumors is limited to case reports and small series and discusses a particular subtype. Here, we report the clinicopathological features and outcomes of all f-PanNETs from a high-volume pancreatectomy center.Methods:A prospectively maintained database was used to identify patients who underwent resection for f-PanNETs between January 1995 and December 2015. Patients were stratified by the type of f-PanNET, and their clinicopathological features and outcomes were analyzed and reported.Results:We identified 69 patients with a mean age of 52 ± 16 years, and the majority were female (62%). The most common type of f-PanNET were insulinomas (70%) followed by gastrinomas (15%), and vasoactive intestinal peptidomas (VIPomas) (10%). There was considerable heterogeneity in the presenting symptoms. Patients with insulinomas presented with smaller tumors compared to the other subtypes. Nodal disease was most frequent in patients with VIPomas (71%), and gastrinomas (50%). The median overall survival (OS) was 7.4 years. Elevated Ki-67 and age >65 years were associated with poorer OS. Recurrence was observed in 8 patients (12%) and was most frequent in patients with VIPomas. Recurrence was associated with a poorer OS (P = .012).Conclusion:f-PanNETs are exceedingly rare and present with a wide variety of symptoms, histopathological findings, and outcomes. Surgical resection can help achieve good long-term survival.

Original languageEnglish (US)
Pages (from-to)29-34
Number of pages6
JournalJournal of Pancreatology
Issue number2
StatePublished - Jun 2019


  • Functional tumor
  • Outcome
  • Pancreatic neuroendocrine tumor

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology


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