Clinicopathologic features of Chandler's syndrome

Arun Patel, Kenneth R. Kenyon, Lawrence W. Hirst, Harry A. Quigley, Walter J. Stark, Roger F. Meyer, W. Richard Green

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


The clinicopathologic features of Chandler's syndrome are elucidated based on a study of nine patients. Keratoplasty, trabeculectomy and/or iris specimens were studied by light, electron and, in six cases, specular microscopy. The prominent pathologic features were abnormalities of the endothelially-derived cells lining the posterior corneal surface, the inner surface of the trabecular meshwork, and the anterior iris surface. In all four corneal buttons, the endothelium was diffusely attenuated and focally absent, and posterior collagen layers were present. Extension of the endothelial cell layer and Descemet's membrane deposition over the trabecular meshwork were observed in two trabeculectomy specimens, and similar proliferation onto the anterior surface of the iris was evident in four iris specimens. Other abnormalities of the endothelial cells included increased intracytoplasmic filaments. These pathologic alterations are consistent with the concept of Chandler's syndrome as representing one variant of the iridocorneal endothelial (ICE) syndrome. Interestingly, although both endothelial proliferative and degenerative responses can be observed in Chandler's syndrome, their occurrence within the same eye is apparently not simultaneous.

Original languageEnglish (US)
Pages (from-to)327-344
Number of pages18
JournalSurvey of ophthalmology
Issue number5
StatePublished - 1983


  • Chandler's syndrome
  • Descemet's membrane
  • clinical specular microscopy
  • cornea
  • corneal endothelial cells
  • electron microscopy
  • epithelial characteristics
  • glaucoma
  • iris
  • posterior collagenous layer
  • trabecular meshwork
  • ultrastructure

ASJC Scopus subject areas

  • Ophthalmology


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