TY - JOUR
T1 - Clinical uses of antiestrogens
AU - Baker, Valerie L.
AU - Jaffe, Robert B.
PY - 1996/1/1
Y1 - 1996/1/1
N2 - An antiestrogen is a compound that blocks the action of estrogen. Most synthetic antiestrogens have agonistic or antagonistic activity depending on the tissue and the endogenous estrogen milieu. The triphenylethylene derivatives, clomiphene and tamoxifen, are the antiestrogens in greatest clinical use. Their biologic effects, clinical indications, and risks are reviewed. Novel antiestrogens which are beginning to be studied clinically include the benzothiophene derivative, raloxifene and the 'pure' antiestrogens such as ICI 182,780. New clinical indications for existing compounds as well as the development of novel antiestrogens may lead to better treatment options for endocrine-dependent conditions.
AB - An antiestrogen is a compound that blocks the action of estrogen. Most synthetic antiestrogens have agonistic or antagonistic activity depending on the tissue and the endogenous estrogen milieu. The triphenylethylene derivatives, clomiphene and tamoxifen, are the antiestrogens in greatest clinical use. Their biologic effects, clinical indications, and risks are reviewed. Novel antiestrogens which are beginning to be studied clinically include the benzothiophene derivative, raloxifene and the 'pure' antiestrogens such as ICI 182,780. New clinical indications for existing compounds as well as the development of novel antiestrogens may lead to better treatment options for endocrine-dependent conditions.
UR - http://www.scopus.com/inward/record.url?scp=0030034607&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030034607&partnerID=8YFLogxK
U2 - 10.1097/00006254-199601000-00021
DO - 10.1097/00006254-199601000-00021
M3 - Review article
C2 - 8657397
AN - SCOPUS:0030034607
SN - 0029-7828
VL - 51
SP - 45
EP - 59
JO - Obstetrical and Gynecological Survey
JF - Obstetrical and Gynecological Survey
IS - 1
ER -