@article{ecd4fce09b164c2caf49003285bfb98a,
title = "Clinical trial discrimination of physical function instruments for psoriatic arthritis: A systematic review",
abstract = "Objectives: Physical function (PF) is a core domain to be measured in randomized controlled trials (RCTs) of psoriatic arthritis (PsA), yet the discriminative performance of patient reported outcome measures (PROMs) for PF in RCTs has not been evaluated systematically. In this systematic review, we aimed to evaluate the clinical trial discrimination of PF-PROMs in PsA RCTs. Methods: We searched PubMed and Scopus databases in English to identify all original RCTs on biological and targeted synthetic disease modifying anti-rheumatic drugs (DMARDs) conducted in PsA. We assessed quality in each article using the OMERACT good method checklist. Effect sizes (ES) for the PF-PROMs were calculated and appraised using a priori hypotheses. Evidence supporting clinical trial discrimination for each PF-PROM was summarized to derive recommendations. Results: 35 articles from 31 RCTs were included. Four PF-PROMs had data for evaluation: HAQ-Disability Index (DI), HAQ-Spondyloarthritis (S), and Short Form 36-item Health Survey Physical Component Summary (SF-36 PCS) and Physical Functioning domain (SF-36 PF). As anticipated, higher ES values were observed for intervention groups than the control groups. Across all studies, for HAQ-DI, the median ES were -0.73 and -0.24 for intervention and control groups, respectively. Whereas for SF-36 PCS, the median ES were 0.77 and 0.23. For intervention and control groups, respectively. Conclusion: Clinical trial discrimination was supported for HAQ-DI and SF-36 PCS in PsA with low risk of bias; and for SF-36 PF and HAQ-S with some caution. More studies are required for HAQ-S.",
keywords = "Clinical trials, Physical function, Psoriatic arthritis, Psychometric, Responsiveness",
author = "Leung, {Ying Ying} and Richard Holland and Mathew, {Ashish J.} and Christine Lindsay and Niti Goel and Alexis Ogdie and Orbai, {Ana Maria} and Pil Hojgaard and Jeffrey Chau and Coates, {Laura C.} and Vibeke Strand and Gladman, {Dafna D.} and Robin Christensen and William Tillett and Philip Mease",
note = "Funding Information: YYL is funded by the Clinician Scientist award of the National Medical Research Council, Singapore (NMRC/CSA-INV/0022/2017). The views expressed are those of the author(s) and not necessarily those of the NMRC. AMO is funded by the Jerome L. Greene Foundation Scholar Award, the Staurulakis Family Discovery Award, the Rheumatology Research Foundation, and the National Institutes of Health (NIH) through the Rheumatic Diseases Resource-based Core Center (P30-AR053503 Cores A and D, and P30-AR070254, Cores A and B). All statements in this report, including its findings and conclusions, are solely those of the authors and do not necessarily represent the views of the NIH, the National Institute of Arthritis Musculoskeletal and Skin Diseases (NIAMS), or the Rheumatology Research Foundation (RRF). LCC is funded by a National Institute for Health Research Clinician Scientist award. The research was supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. AO is funded by the Rheumatology Research Foundation and NIH/NIAMS R01 AR072363. The Parker Institute, Bispebjerg and Frederiksberg Hospital (PH and RC) is supported by a core grant from the Oak Foundation (OCAY-18–774-OFIL). Funding Information: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. YYL is funded by the Clinician Scientist award of the National Medical Research Council, Singapore (NMRC/CSA-INV/0022/2017). AMO is funded by the Jerome L. Greene Foundation Scholar Award, the Staurulakis Family Discovery Award, the Rheumatology Research Foundation, and the National Institutes of Health (NIH) through the Rheumatic Diseases Resource-based Core Center (P30-AR053503 Cores A and D, and P30-AR070254, Cores A and B). PH and RC (The Parker Institute, Bispebjerg and Frederiksberg Hospital) is supported by a core grant from the Oak Foundation (OCAY-18–774-OFIL). LCC is funded by a National Institute for Health Research Clinician Scientist award, and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). AO is funded by the Rheumatology Research Foundation and NIH/NIAMS R01 AR072363. All statements in this report, including its findings and conclusions, are solely those of the authors and do not necessarily represent the views of the funding agencies. Funding Information: YYL is funded by the Clinician Scientist award of the National Medical Research Council, Singapore ( NMRC/CSA-INV/0022/2017 ). The views expressed are those of the author(s) and not necessarily those of the NMRC. AMO is funded by the Jerome L. Greene Foundation Scholar Award , the Staurulakis Family Discovery Award , the Rheumatology Research Foundation , and the National Institutes of Health (NIH) through the Rheumatic Diseases Resource-based Core Center ( P30-AR053503 Cores A and D, and P30-AR070254 , Cores A and B). All statements in this report, including its findings and conclusions, are solely those of the authors and do not necessarily represent the views of the NIH, the National Institute of Arthritis Musculoskeletal and Skin Diseases (NIAMS), or the Rheumatology Research Foundation (RRF). LCC is funded by a National Institute for Health Research Clinician Scientist award. The research was supported by the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC). The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR, or the Department of Health. AO is funded by the Rheumatology Research Foundation and NIH/NIAMS R01 AR072363 . The Parker Institute, Bispebjerg and Frederiksberg Hospital (PH and RC) is supported by a core grant from the Oak Foundation ( OCAY-18–774-OFIL ). Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2020",
month = oct,
doi = "10.1016/j.semarthrit.2020.05.022",
language = "English (US)",
volume = "50",
pages = "1158--1181",
journal = "Seminars in Arthritis and Rheumatism",
issn = "0049-0172",
publisher = "W.B. Saunders Ltd",
number = "5",
}