Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia

L. E. Tune; I. Creese; J. R. DePaulo; P. R. Slavney; J. T. Coyle; S. H. Snyder

doi:10.1176/ajp.137.2.187

Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia

L. E. Tune, I. Creese, J. R. DePaulo, P. R. Slavney, J. T. Coyle, S. H. Snyder

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

The authors measured serum neuroleptic levels by radioreceptor assay in 30 schizophrenic patients receiving haloperidol, fluphenazine, chlorpromazine, molindone, thiothixene, or trifluoperazine. Neuroleptic levels were significantly correlated with clinical state, monitored by an abbreviated version of the Present State Examination (the mini-PSE). Poor therapeutic responses were associated with serum levels under 50 μg/ml chlorpromazine equivalents. There was no correlation between neuroleptic dosage and mini-PSE score or between neuroleptic dose and serum neuroleptic levels.

Original language	English (US)
Pages (from-to)	187-190
Number of pages	4
Journal	American Journal of Psychiatry
Volume	137
Issue number	2
DOIs	https://doi.org/10.1176/ajp.137.2.187
State	Published - 1980

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1176/ajp.137.2.187

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abstract = "The authors measured serum neuroleptic levels by radioreceptor assay in 30 schizophrenic patients receiving haloperidol, fluphenazine, chlorpromazine, molindone, thiothixene, or trifluoperazine. Neuroleptic levels were significantly correlated with clinical state, monitored by an abbreviated version of the Present State Examination (the mini-PSE). Poor therapeutic responses were associated with serum levels under 50 μg/ml chlorpromazine equivalents. There was no correlation between neuroleptic dosage and mini-PSE score or between neuroleptic dose and serum neuroleptic levels.",

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AU - Coyle, J. T.

AU - Snyder, S. H.

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AB - The authors measured serum neuroleptic levels by radioreceptor assay in 30 schizophrenic patients receiving haloperidol, fluphenazine, chlorpromazine, molindone, thiothixene, or trifluoperazine. Neuroleptic levels were significantly correlated with clinical state, monitored by an abbreviated version of the Present State Examination (the mini-PSE). Poor therapeutic responses were associated with serum levels under 50 μg/ml chlorpromazine equivalents. There was no correlation between neuroleptic dosage and mini-PSE score or between neuroleptic dose and serum neuroleptic levels.

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Clinical state and serum neuroleptic levels measured by radioreceptor assay in schizophrenia

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