Clinical significance of antinuclear antibodies with hypocomplementemia

J. L. Morris, T. M. Zizic, L. E. Shulman, M. B. Stevens

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Eighty five percent of patients with reduced serum complement and antinuclear antibodies on initial evaluation were found to have systemic lupus erythematosus (SLE). The more marked the degree of complement depression, the more frequent was renal involvement on clinical and histological grounds. In patients with lupus nephritis proven on renal biopsy, with hypocomplementemia, 18% had no clinical or laboratory evidence of renal involvement.

Original languageEnglish (US)
Pages (from-to)321-328
Number of pages8
JournalJohns Hopkins Medical Journal
Issue number6
StatePublished - 1973
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine


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