Clinical Reasoning: A 63-Year-Old Man With Progressive Multicranial Neuropathy and Leptomeningeal Enhancement

Arens Taga, Carlos G. Romo, Sharika Rajan, Doris Lin, Grace Tobin, Arun Venkatesan, Carlos A. Pardo

Research output: Contribution to journalArticlepeer-review

Abstract

A 63-year-old man, with a history of melanoma and basal cell carcinoma, presented with progressive right-sided facial numbness, vertical diplopia, and headache. Brain MRI revealed leptomeningeal enhancement of multiple cranial nerves and an enhancing mass-like lesion along the anterolateral surface of the pons and midbrain. Subsequent brain biopsy demonstrated the final diagnosis. This case highlights the broad differential diagnosis of leptomeningeal disease, emphasizing the role of specific clinical, laboratory, and imaging cues in guiding clinical reasoning.

Original languageEnglish (US)
Article numbere210100
JournalNeurology
Volume103
Issue number12
DOIs
StatePublished - Nov 25 2024

ASJC Scopus subject areas

  • Clinical Neurology

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