@article{83c3dc825d5e4de787977adfd52d3df7,
title = "Clinical pharmacology in HIV therapy",
abstract = "The success of combination antiretroviral therapy in the treatment ofHIV-1-positive individuals has shifted clinical attention toward combination antiretroviral drug regimens that optimize tolerability, long-term safety, and durable efficacy.Wherever patients have access to treatment, morbidity and mortality are increasingly driven by non-HIV-associated comorbidities, which may be observed earlier than in age-matched controls and despite the best available combination antiretroviral therapy. Similarly, HIV-1-positive individuals are now diagnosed and treated earlier with anticipated lifelong therapy. The contribution of specific antiretroviral agents to long-term morbidity and mortality is dependent on the pharmacologic characteristics of these agents, and it is increasingly important in this context.",
author = "Atta, {Mohamed G.} and {De Seigneux}, Sophie and Lucas, {Gregory M.}",
note = "Funding Information: M.G.A. was supported by National Institutes of Health (NIH)/ National Institute of Diabetes and Digestive and Kidney Diseases grant P01DK056492, NIH grant 7R01 DK103574-03 (subaward EST2041-01), and National Institute on Drug Abuse grant R01DA026770. G.M.L. was supported by National Institute on Drug Abuse grants K24 DA035684 and R01 DA026770 and Johns Hopkins University Center for AIDS Research grant P30 AI094189. Funding Information: M.G.A. was supported by National Institutes of Health (NIH)/ National Institute of Diabetes and Digestive and Kidney Diseases grant P01DK056492, NIH grant 7R01 DK103574-03 (suba-ward EST2041-01), and National Institute on Drug Abuse grant R01DA026770. G.M.L. was supported by National Institute on Drug Abuse grants K24 DA035684 and R01 DA026770 and Johns Hopkins University Center for AIDS Research grant P30 AI094189. Publisher Copyright: {\textcopyright} 2019 by the American Society of Nephrology.",
year = "2019",
month = mar,
day = "7",
doi = "10.2215/CJN.02240218",
language = "English (US)",
volume = "14",
pages = "435--444",
journal = "Clinical Journal of the American Society of Nephrology",
issn = "1555-9041",
publisher = "American Society of Nephrology",
number = "3",
}