Clinical implications of the p53 gene

David Sidransky, Monica Hollstein

Research output: Contribution to journalReview articlepeer-review

160 Scopus citations


The capacity for malignant growth is acquired by the stepwise accumulation of defects in specific genes regulating cell growth and tissue homeostasis. Although several hundred genes are known to control growth, molecular genetic studies in cancer show that few of these are consistently involved in the natural history of human cancer, and those typically in only certain types of malignancy. Prospects for development of molecular-based diagnostic and therapeutic strategies with widespread application did not look promising, until it was realized that the p53 tumor suppressor gene was defective in approximately half of all malignancies. This discovery generated research efforts of unparalleled intensity to determine how p53 functions at the molecular level, and how to apply this knowledge to clinical ends.

Original languageEnglish (US)
Pages (from-to)285-301
Number of pages17
JournalAnnual review of medicine
StatePublished - 1996


  • Apoptosis
  • Cell cycle
  • Clonality
  • Molecular diagnostics
  • Mutation

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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