Clinical features related to statin-associated muscle symptoms

Heather M. Ochs-Balcom, Ly Minh Nguyen, Changxing Ma, Paul J. Isackson, Jasmine A. Luzum, Joseph P. Kitzmiller, Mark Tarnopolsky, Michael Weisman, Lisa Christopher-Stine, Wendy Peltier, Robert L. Wortmann, Georgirene D. Vladutiu

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Introduction: Statins reduce cardiovascular disease risk and are generally well tolerated, yet up to 0.5% of statin-treated patients develop incapacitating muscle symptoms including rhabdomyolysis. Our objective was to identify clinical factors related to statin-associated muscle symptoms (SAMS). Methods: Clinical and laboratory characteristics were evaluated in 748 statin-treated Caucasians (634 with SAMS and 114 statin-tolerant controls). Information was collected on statin type, concomitant drug therapies, muscle symptom history, comorbidities, and family history. Logistic regression was used to identify associations. Results: Individuals with SAMS were 3.6 times (odds ratio [OR] 3.60, 95% confidence interval [CI] 2.08-6.22) more likely than statin-tolerant controls to have a family history of heart disease. Additional associations included obesity (OR 3.08, 95% CI 1.18, 8.05), hypertension (OR 2.24, 95% CI 1.33, 3.77), smoking (OR 2.08, 95% CI 1.16, 3.74), and statin type. Discussion: Careful medical monitoring of statin-treated patients with the associated coexisting conditions may ultimately reduce muscle symptoms and lead to improved compliance. Muscle Nerve 59:537–537, 2019.

Original languageEnglish (US)
Pages (from-to)537-543
Number of pages7
JournalMuscle and Nerve
Issue number5
StatePublished - May 2019


  • muscle disease
  • rhabdomyolysis
  • risk factors
  • statin-associated muscle symptoms
  • statins

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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