Clinical evaluation of immunological methods for detection of serum prostatic acid phosphatase

J. E. Pontes; B. K. Choe; N. R. Rose; C. Ercole; J. M. Pierce

doi:10.1016/S0022-5347(17)54528-0

Clinical evaluation of immunological methods for detection of serum prostatic acid phosphatase

J. E. Pontes, B. K. Choe, N. R. Rose, C. Ercole, J. M. Pierce

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Evaluation of serum acid phosphatase by 3 immunochemical methods (radioimmunoassay, counterimmunoelectrophoresis and immunoenzymoassay was done in 3 groups of patients. In 42 patients with stage D prostatic carcinoma a comparison of serum acid phosphatase determination by colorimetric assay and the 3 immunochemical methods in samples obtained before and after initiation of therapy showed an excellent correlation among the assays. Presently, we see no advantage of the immunochemical methods over the colorimetric assay in this group of patients. Among 100 patients studied in a blind fashion to detect those with unsuspected prostatic carcinoma no such cases were found. In the last group of patients with localized prostatic carcinoma staged surgically by pelvic lymphadenectomy the only elevations of serum acid phosphatase were observed in patients with extraprostatic involvement.

Original language	English (US)
Pages (from-to)	363-365
Number of pages	3
Journal	Unknown Journal
Volume	126
Issue number	3
DOIs	https://doi.org/10.1016/S0022-5347(17)54528-0
State	Published - 1981
Externally published	Yes

ASJC Scopus subject areas

Urology

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10.1016/S0022-5347(17)54528-0

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title = "Clinical evaluation of immunological methods for detection of serum prostatic acid phosphatase",

abstract = "Evaluation of serum acid phosphatase by 3 immunochemical methods (radioimmunoassay, counterimmunoelectrophoresis and immunoenzymoassay was done in 3 groups of patients. In 42 patients with stage D prostatic carcinoma a comparison of serum acid phosphatase determination by colorimetric assay and the 3 immunochemical methods in samples obtained before and after initiation of therapy showed an excellent correlation among the assays. Presently, we see no advantage of the immunochemical methods over the colorimetric assay in this group of patients. Among 100 patients studied in a blind fashion to detect those with unsuspected prostatic carcinoma no such cases were found. In the last group of patients with localized prostatic carcinoma staged surgically by pelvic lymphadenectomy the only elevations of serum acid phosphatase were observed in patients with extraprostatic involvement.",

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year = "1981",

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T1 - Clinical evaluation of immunological methods for detection of serum prostatic acid phosphatase

AU - Pontes, J. E.

AU - Choe, B. K.

AU - Rose, N. R.

AU - Ercole, C.

AU - Pierce, J. M.

PY - 1981

Y1 - 1981

N2 - Evaluation of serum acid phosphatase by 3 immunochemical methods (radioimmunoassay, counterimmunoelectrophoresis and immunoenzymoassay was done in 3 groups of patients. In 42 patients with stage D prostatic carcinoma a comparison of serum acid phosphatase determination by colorimetric assay and the 3 immunochemical methods in samples obtained before and after initiation of therapy showed an excellent correlation among the assays. Presently, we see no advantage of the immunochemical methods over the colorimetric assay in this group of patients. Among 100 patients studied in a blind fashion to detect those with unsuspected prostatic carcinoma no such cases were found. In the last group of patients with localized prostatic carcinoma staged surgically by pelvic lymphadenectomy the only elevations of serum acid phosphatase were observed in patients with extraprostatic involvement.

AB - Evaluation of serum acid phosphatase by 3 immunochemical methods (radioimmunoassay, counterimmunoelectrophoresis and immunoenzymoassay was done in 3 groups of patients. In 42 patients with stage D prostatic carcinoma a comparison of serum acid phosphatase determination by colorimetric assay and the 3 immunochemical methods in samples obtained before and after initiation of therapy showed an excellent correlation among the assays. Presently, we see no advantage of the immunochemical methods over the colorimetric assay in this group of patients. Among 100 patients studied in a blind fashion to detect those with unsuspected prostatic carcinoma no such cases were found. In the last group of patients with localized prostatic carcinoma staged surgically by pelvic lymphadenectomy the only elevations of serum acid phosphatase were observed in patients with extraprostatic involvement.

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Clinical evaluation of immunological methods for detection of serum prostatic acid phosphatase

Abstract

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