Clinical evaluation of a new live measles vaccine derived in chick chorioallantoic membranes

Neal A. Halsey; Leonard B. Weiner; Martin G. Meyers; Kenneth L. Herrmann; Alan Hinman

doi:10.1016/S0092-1157(81)80043-1

Clinical evaluation of a new live measles vaccine derived in chick chorioallantoic membranes

Neal A. Halsey, Leonard B. Weiner, Martin G. Meyers, Kenneth L. Herrmann, Alan Hinman

Research output: Contribution to journal › Article › peer-review

Abstract

A new measles vaccine (CAM) prepared in chick chorioallantoic membranes was compared with the routinely used measles vaccine (Attenuvax, Merck, Sharpe and Dohme) prepared in chick embryo tissue culture for immunogenicity and adverse reactions in 77 children. Recipients of the CAM vaccine developed significantly (P = 0·001) higher hemagglutination-inhibition (HI) geometric mean antibody titers (83·3 v. 42·8) than did recipients of Attenuvax. CAM vaccine recipients also experienced significantly (P < 0·01) higher rates of fever and rash in the period 6-15 days after vaccination. Although the CAM vaccine was more immunogenic than Attenuvax, the higher rates of fever and rash make the vaccine unacceptable for routine primary vaccination of children.

Original language	English (US)
Pages (from-to)	507-511
Number of pages	5
Journal	Journal of Biological Standardization
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/S0092-1157(81)80043-1
State	Published - Oct 1981
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/S0092-1157(81)80043-1

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@article{cc8fd61654c94604b66a967c6e76dcb0,

title = "Clinical evaluation of a new live measles vaccine derived in chick chorioallantoic membranes",

abstract = "A new measles vaccine (CAM) prepared in chick chorioallantoic membranes was compared with the routinely used measles vaccine (Attenuvax, Merck, Sharpe and Dohme) prepared in chick embryo tissue culture for immunogenicity and adverse reactions in 77 children. Recipients of the CAM vaccine developed significantly (P = 0·001) higher hemagglutination-inhibition (HI) geometric mean antibody titers (83·3 v. 42·8) than did recipients of Attenuvax. CAM vaccine recipients also experienced significantly (P < 0·01) higher rates of fever and rash in the period 6-15 days after vaccination. Although the CAM vaccine was more immunogenic than Attenuvax, the higher rates of fever and rash make the vaccine unacceptable for routine primary vaccination of children.",

author = "Halsey, {Neal A.} and Weiner, {Leonard B.} and Meyers, {Martin G.} and Herrmann, {Kenneth L.} and Alan Hinman",

note = "Funding Information: This work was supported in part by the Bureau of Biologics, Food and Drug Administration. The authors express their gratitude to Shercy Handley, I~N~\[,P NP and Alice Chico, Rlq, MS, PNP for their assistance. Dr James Nakano (CDC Atlanta) performed the viral titrations. Dennis Luckey assisted with the statistical analyses. Dr Geoffry Kalish provided a critical evaluation of the data and Lederle Laboratories provided the measles vaccines. Kris Magee and Peggy Stoudenmire provided secretarial assistance.",

year = "1981",

month = oct,

doi = "10.1016/S0092-1157(81)80043-1",

language = "English (US)",

volume = "9",

pages = "507--511",

journal = "Journal of Biological Standardization",

issn = "0092-1157",

publisher = "Academic Press",

number = "4",

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AU - Halsey, Neal A.

AU - Weiner, Leonard B.

AU - Meyers, Martin G.

AU - Herrmann, Kenneth L.

AU - Hinman, Alan

N1 - Funding Information: This work was supported in part by the Bureau of Biologics, Food and Drug Administration. The authors express their gratitude to Shercy Handley, I~N~\[,P NP and Alice Chico, Rlq, MS, PNP for their assistance. Dr James Nakano (CDC Atlanta) performed the viral titrations. Dennis Luckey assisted with the statistical analyses. Dr Geoffry Kalish provided a critical evaluation of the data and Lederle Laboratories provided the measles vaccines. Kris Magee and Peggy Stoudenmire provided secretarial assistance.

PY - 1981/10

Y1 - 1981/10

N2 - A new measles vaccine (CAM) prepared in chick chorioallantoic membranes was compared with the routinely used measles vaccine (Attenuvax, Merck, Sharpe and Dohme) prepared in chick embryo tissue culture for immunogenicity and adverse reactions in 77 children. Recipients of the CAM vaccine developed significantly (P = 0·001) higher hemagglutination-inhibition (HI) geometric mean antibody titers (83·3 v. 42·8) than did recipients of Attenuvax. CAM vaccine recipients also experienced significantly (P < 0·01) higher rates of fever and rash in the period 6-15 days after vaccination. Although the CAM vaccine was more immunogenic than Attenuvax, the higher rates of fever and rash make the vaccine unacceptable for routine primary vaccination of children.

AB - A new measles vaccine (CAM) prepared in chick chorioallantoic membranes was compared with the routinely used measles vaccine (Attenuvax, Merck, Sharpe and Dohme) prepared in chick embryo tissue culture for immunogenicity and adverse reactions in 77 children. Recipients of the CAM vaccine developed significantly (P = 0·001) higher hemagglutination-inhibition (HI) geometric mean antibody titers (83·3 v. 42·8) than did recipients of Attenuvax. CAM vaccine recipients also experienced significantly (P < 0·01) higher rates of fever and rash in the period 6-15 days after vaccination. Although the CAM vaccine was more immunogenic than Attenuvax, the higher rates of fever and rash make the vaccine unacceptable for routine primary vaccination of children.

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Clinical evaluation of a new live measles vaccine derived in chick chorioallantoic membranes

Abstract

ASJC Scopus subject areas

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