TY - JOUR
T1 - Clinical, cortical thickness and neural activity predictors of future affective lability in youth at risk for bipolar disorder
T2 - initial discovery and independent sample replication
AU - Bertocci, Michele A.
AU - Hanford, Lindsay
AU - Manelis, Anna
AU - Iyengar, Satish
AU - Youngstrom, Eric A.
AU - Gill, Mary Kay
AU - Monk, Kelly
AU - Versace, Amelia
AU - Bonar, Lisa
AU - Bebko, Genna
AU - Ladouceur, Cecile D.
AU - Perlman, Susan B.
AU - Diler, Rasim
AU - Horwitz, Sarah M.
AU - Arnold, L. Eugene
AU - Hafeman, Danella
AU - Travis, Michael J.
AU - Kowatch, Robert
AU - Holland, Scott K.
AU - Fristad, Mary A.
AU - Findling, Robert L.
AU - Birmaher, Boris
AU - Phillips, Mary L.
N1 - Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2019/12/1
Y1 - 2019/12/1
N2 - We aimed to identify markers of future affective lability in youth at bipolar disorder risk from the Pittsburgh Bipolar Offspring Study (BIOS) (n = 41, age = 14, SD = 2.30), and validate these predictors in an independent sample from the Longitudinal Assessment of Manic Symptoms study (LAMS) (n = 55, age = 13.7, SD = 1.9). We included factors of mixed/mania, irritability, and anxiety/depression (29 months post MRI scan) in regularized regression models. Clinical and demographic variables, along with neural activity during reward and emotion processing and gray matter structure in all cortical regions at baseline, were used to predict future affective lability factor scores, using regularized regression. Future affective lability factor scores were predicted in both samples by unique combinations of baseline neural structure, function, and clinical characteristics. Lower bilateral parietal cortical thickness, greater left ventrolateral prefrontal cortex thickness, lower right transverse temporal cortex thickness, greater self-reported depression, mania severity, and age at scan predicted greater future mixed/mania factor score. Lower bilateral parietal cortical thickness, greater right entorhinal cortical thickness, greater right fusiform gyral activity during emotional face processing, diagnosis of major depressive disorder, and greater self-reported depression severity predicted greater irritability factor score. Greater self-reported depression severity predicted greater anxiety/depression factor score. Elucidating unique clinical and neural predictors of future-specific affective lability factors is a step toward identifying objective markers of bipolar disorder risk, to provide neural targets to better guide and monitor early interventions in bipolar disorder at-risk youth.
AB - We aimed to identify markers of future affective lability in youth at bipolar disorder risk from the Pittsburgh Bipolar Offspring Study (BIOS) (n = 41, age = 14, SD = 2.30), and validate these predictors in an independent sample from the Longitudinal Assessment of Manic Symptoms study (LAMS) (n = 55, age = 13.7, SD = 1.9). We included factors of mixed/mania, irritability, and anxiety/depression (29 months post MRI scan) in regularized regression models. Clinical and demographic variables, along with neural activity during reward and emotion processing and gray matter structure in all cortical regions at baseline, were used to predict future affective lability factor scores, using regularized regression. Future affective lability factor scores were predicted in both samples by unique combinations of baseline neural structure, function, and clinical characteristics. Lower bilateral parietal cortical thickness, greater left ventrolateral prefrontal cortex thickness, lower right transverse temporal cortex thickness, greater self-reported depression, mania severity, and age at scan predicted greater future mixed/mania factor score. Lower bilateral parietal cortical thickness, greater right entorhinal cortical thickness, greater right fusiform gyral activity during emotional face processing, diagnosis of major depressive disorder, and greater self-reported depression severity predicted greater irritability factor score. Greater self-reported depression severity predicted greater anxiety/depression factor score. Elucidating unique clinical and neural predictors of future-specific affective lability factors is a step toward identifying objective markers of bipolar disorder risk, to provide neural targets to better guide and monitor early interventions in bipolar disorder at-risk youth.
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U2 - 10.1038/s41380-018-0273-4
DO - 10.1038/s41380-018-0273-4
M3 - Article
C2 - 31628415
AN - SCOPUS:85055252353
SN - 1359-4184
VL - 24
SP - 1856
EP - 1867
JO - Molecular Psychiatry
JF - Molecular Psychiatry
IS - 12
ER -