TY - JOUR
T1 - Clinical considerations of coagulopathy in acute liver failure
AU - Kim, Ahyoung
AU - Niu, Bolin
AU - Woreta, Tinsay
AU - Chen, Po Hung
N1 - Funding Information:
This work was supported by the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under award number K23AA028297 (to PHC) and Johns Hopkins University Clinician Scientist Award (to PHC). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 Authors.
PY - 2020
Y1 - 2020
N2 - Acute liver failure (ALF) is the rapid onset of severe liver dysfunction, defined by the presence of hepatic encephalop-athy and impaired synthetic function (international normalized ratio of ≥1.5) in the absence of underlying liver disease. The elevated international normalized ratio value in ALF is often misinterpreted as an increased hemorrhagic tendency, which can lead to inappropriate, prophylactic transfusions of blood products. However, global assessments of coagulop-athy via viscoelastic tests or thrombin generation assay suggest a reestablished hemostatic, or even hypercoagu-lable, status in patients with ALF. Although the current versions of global assays are not perfect, they can provide more nuanced insights into the hemostatic system in ALF than the conventional measures of coagulopathy. Citation of this article: Kim A, Niu B, Woreta T, Chen PH. Clinical considerations of coagulopathy in acute liver failure.
AB - Acute liver failure (ALF) is the rapid onset of severe liver dysfunction, defined by the presence of hepatic encephalop-athy and impaired synthetic function (international normalized ratio of ≥1.5) in the absence of underlying liver disease. The elevated international normalized ratio value in ALF is often misinterpreted as an increased hemorrhagic tendency, which can lead to inappropriate, prophylactic transfusions of blood products. However, global assessments of coagulop-athy via viscoelastic tests or thrombin generation assay suggest a reestablished hemostatic, or even hypercoagu-lable, status in patients with ALF. Although the current versions of global assays are not perfect, they can provide more nuanced insights into the hemostatic system in ALF than the conventional measures of coagulopathy. Citation of this article: Kim A, Niu B, Woreta T, Chen PH. Clinical considerations of coagulopathy in acute liver failure.
KW - Acute liver failure
KW - Coagulopathy
KW - Thrombin generation assay
KW - Viscoelastic test
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U2 - 10.14218/JCTH.2020.00058
DO - 10.14218/JCTH.2020.00058
M3 - Article
C2 - 33447524
AN - SCOPUS:85099023664
SN - 2225-0719
VL - 8
SP - 407
EP - 413
JO - Journal of Clinical and Translational Hepatology
JF - Journal of Clinical and Translational Hepatology
IS - 4
ER -