Clinical characteristics of vitamin A responsive and nonresponsive Bitot's spots

A. Sommer, N. Emran, S. Tjakrasudjatma

Research output: Contribution to journalArticlepeer-review

36 Scopus citations


We examined and followed up 59 patients with conjunctival xerosis with and without classic Bitot's spots. Of these, 50 were responsive and nine were unresponsive to vitamin A. Despite a recent World Health Organization classification suggesting otherwise, all cases appeared to represent the same process. In preschool children, the presence of the Bitot's spots on both sides of the corneoscleral limbus or punctate keratopathy suggests active vitamin A deficiency. Pigmentation and wrinkling were not useful diagnostic criteria and lesions isolated to the nasal corneoscleral limbus suggested a different diagnosis. At least some cases of nonresponsive conjunctival xerosis and Bitot's spots were probably sequelae of past vitamin A deficiency.

Original languageEnglish (US)
Pages (from-to)160-163
Number of pages4
JournalAmerican journal of ophthalmology
Issue number2
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Clinical characteristics of vitamin A responsive and nonresponsive Bitot's spots'. Together they form a unique fingerprint.

Cite this