Clinical Characteristics of Patients with Chronic Rhinosinusitis with Nasal Polyps, Asthma, and Aspirin-Exacerbated Respiratory Disease

Whitney W. Stevens, Anju T. Peters, Annemarie G. Hirsch, Cara M. Nordberg, Brian S. Schwartz, Dione G. Mercer, Mahboobeh Mahdavinia, Leslie C. Grammer, Kathryn E. Hulse, Robert C. Kern, Pedro Avila, Robert P. Schleimer

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Background Aspirin-exacerbated respiratory disease (AERD) comprises the triad of chronic rhinosinusitis with nasal polyps (CRSwNP), asthma, and intolerance to inhibitors of the cyclooxygenase-1 (COX-1) enzyme. The prevalence of AERD remains unclear, and few studies have compared the clinical characteristics of patients with AERD to those with CRSwNP alone, asthma alone, or both CRSwNP and asthma. Objective To determine the prevalence of AERD within a tertiary care setting, and to identify unique clinical features that could distinguish these patients from those with both CRSwNP and asthma or with CRSwNP alone. Methods Electronic medical records of patients at Northwestern in Chicago, Illinois, were searched by computer algorithm and then manual chart review to identify 459 patients with CRSwNP alone, 412 with both CRSwNP and asthma, 171 with AERD, and 300 with asthma only. Demographic and clinical features including sex, atopy, and sinus disease severity were characterized. Results The prevalence of AERD among patients with CRSwNP was 16%. Patients with AERD had undergone 2-fold more sinus surgeries (P <.001) and were significantly younger at the time of their first surgery (40 ± 13 years) than were patients with CRSwNP (43 ± 14 years; P <.05). Atopy was significantly more prevalent in patients with AERD (84%) or asthma (85%) than in patients with CRSwNP (66%, P <.05). More patients with AERD (13%) had corticosteroid-dependent disease than patients with both CRSwNP and asthma (4%, P <.01) or asthma (1%, P <.001). Conclusions AERD is common among patients with CRSwNP; even though patients with AERD have CRSwNP and asthma, the clinical course of their disease is not the same as of patients who have CRSwNP and asthma but are tolerant to COX-1 inhibitors.

Original languageEnglish (US)
Pages (from-to)1061-1070.e3
JournalJournal of Allergy and Clinical Immunology: In Practice
Issue number4
StatePublished - Jul 2017


  • AERD
  • Asthma
  • CRS
  • CRSwNP
  • Samter's disease
  • Sinus

ASJC Scopus subject areas

  • Immunology and Allergy


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