TY - JOUR
T1 - Clinical characteristics and risk factors of pulmonary hypertension associated with chronic respiratory diseases
T2 - A retrospective study
AU - Chen, Yonghua
AU - Liu, Chunli
AU - Lu, Wenju
AU - Li, Mengxi
AU - Hadadi, Cyrus
AU - Wang, Elizabeth Wenqian
AU - Yang, Kai
AU - Lai, Ning
AU - Huang, Junyi
AU - Li, Shiyue
AU - Zhong, Nanshan
AU - Zhang, Nuofu
AU - Wang, Jian
N1 - Publisher Copyright:
© Journal of Thoracic Disease.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Background: Chronic respiratory disease-associated pulmonary hypertension (PH) is an important subtype of PH, which lacks clinical epidemiological data in China. Methods: Six hundred and ninety three patients hospitalized from 2010 to 2013 were classified by echocardiography according to pulmonary arterial systolic pressure (PASP): Mild (36 ≤ PASP < 50 mmHg); moderate (50 ≤ PASP < 70 mmHg) and severe (PASP ≥ 70 mmHg). Results: Dyspnea (93.51%) was the most common symptom. Hemoptysis observed in the severe group (6.42%) was significantly higher than the other two groups (P < 0.05). COPD (78.35%), lung bullae (44.16%), tuberculosis (including obsolete pulmonary tuberculosis) (38.82%), and bronchiectasis (30.45%) were frequently present. Mild group occupied the highest proportion (84.7%) in COPD, while severe group occupied the highest proportion (19.3%) in pulmonary embolism (P < 0.01). Age, partial pressure of oxygen (PaO2), hematocrit (HCT), partial pressure of carbon dioxide (PaCO2), increase of N-terminal pro brain natriuretic peptide (NT-proBNP) and right ventricular (RV) diameter (> 20 mm) were associated with moderate-to-severe PH, while RV [odds ratio (OR) =3.53, 95% CI, 2.17-5.74], NT-proBNP (OR=2.44, 95% CI, 1.51-3.95), HCT (OR=1.03, 95% CI, 1.00-1.07) and PaCO2 (OR=1.01, 95% CI, 1.00-1.03) were independent risk factors. Conclusions: PH related to respiratory diseases is mostly mild to moderate, and the severity is associated with the category of respiratory disease. Increased HCT can be an independent risk factor for PH related to chronic respiratory diseases.
AB - Background: Chronic respiratory disease-associated pulmonary hypertension (PH) is an important subtype of PH, which lacks clinical epidemiological data in China. Methods: Six hundred and ninety three patients hospitalized from 2010 to 2013 were classified by echocardiography according to pulmonary arterial systolic pressure (PASP): Mild (36 ≤ PASP < 50 mmHg); moderate (50 ≤ PASP < 70 mmHg) and severe (PASP ≥ 70 mmHg). Results: Dyspnea (93.51%) was the most common symptom. Hemoptysis observed in the severe group (6.42%) was significantly higher than the other two groups (P < 0.05). COPD (78.35%), lung bullae (44.16%), tuberculosis (including obsolete pulmonary tuberculosis) (38.82%), and bronchiectasis (30.45%) were frequently present. Mild group occupied the highest proportion (84.7%) in COPD, while severe group occupied the highest proportion (19.3%) in pulmonary embolism (P < 0.01). Age, partial pressure of oxygen (PaO2), hematocrit (HCT), partial pressure of carbon dioxide (PaCO2), increase of N-terminal pro brain natriuretic peptide (NT-proBNP) and right ventricular (RV) diameter (> 20 mm) were associated with moderate-to-severe PH, while RV [odds ratio (OR) =3.53, 95% CI, 2.17-5.74], NT-proBNP (OR=2.44, 95% CI, 1.51-3.95), HCT (OR=1.03, 95% CI, 1.00-1.07) and PaCO2 (OR=1.01, 95% CI, 1.00-1.03) were independent risk factors. Conclusions: PH related to respiratory diseases is mostly mild to moderate, and the severity is associated with the category of respiratory disease. Increased HCT can be an independent risk factor for PH related to chronic respiratory diseases.
KW - Clinical features
KW - Pulmonary hypertension
KW - Respiratory diseases
KW - Risk factors
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U2 - 10.21037/jtd.2016.02.58
DO - 10.21037/jtd.2016.02.58
M3 - Article
C2 - 27076929
AN - SCOPUS:84962159643
SN - 2072-1439
VL - 8
SP - 350
EP - 358
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
IS - 3
ER -