Clinical cerenkov luminescence imaging of 18F-FDG

Daniel L.J. Thorek, Christopher C. Riedl, Jan Grimm

Research output: Contribution to journalArticlepeer-review

106 Scopus citations


The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18FFDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.

Original languageEnglish (US)
Pages (from-to)95-98
Number of pages4
JournalJournal of Nuclear Medicine
Issue number1
StatePublished - Jan 1 2014
Externally publishedYes


  • Cerenkov luminescence imaging
  • Clinical
  • PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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