Clinical application of operationalized criteria for 'Depression of Alzheimer's Disease'

Paul B. Rosenberg, Chiadi U. Onyike, Ira R. Katz, Anton P. Porsteinsson, Jacobo E. Mintzer, Lon S. Schneider, Peter V. Rabins, Curtis L. Meinert, Barbara K. Martin, Constantine G. Lyketsos

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Objectives: 'Depression of Alzheimer's Disease' (dAD) is a common complication of Alzheimer's disease and is increasingly recognized as a syndrome with a clinical presentation differing from major depression. Criteria for the diagnosis of dAD have been proposed previously. Methods: This paper presents these criteria in operationalized format designed to be accessible for clinical use. Four cases are discussed that demonstrate the use of these criteria and illustrate important differences between dAD and major depression. Results: The daD criteria are broader than DSM-IV criteria for Major Depressive Episode and incorporate caregiver input. Conclusions: Given the differences between dAD and major depression diagnoses, it is important to assess the efficacy of treatments for dAD. Depression in Alzheimer's Disease-2 (DIADS-2) is a controlled trial of dAD treatments that will also assess the validity of these criteria.

Original languageEnglish (US)
Pages (from-to)119-127
Number of pages9
JournalInternational journal of geriatric psychiatry
Issue number2
StatePublished - Feb 2005


  • Alzheimer
  • Dementia
  • Depression
  • Diagnosis
  • Mood disorder

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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