Clinical application of breath biomarkers of oxidative stress status

Terence H. Risby, Shelley S. Sehnert

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


Isolation and quantification of volatile breath biomarkers indicative of relevant alterations in clinical status has required development of new techniques and applications of existing analytical chemical methods. The most significant obstacles to successful application of this type of sample have been reduction in required sample volume permitting replicate analysis (an absolute requirement for all clinical studies), separation of the analyte(s) of interest from background molecules, water vapor and other molecules with similar physical properties, introduction of automation in analysis and the use of selective detection systems (electron impact mass spectrometry, flame photometric, thermionic detectors), and automated sample collection from the human subject. Advances in adsorption technology and trace gas analysis have permitted rapid progress in this area of clinical chemistry. Copyright (C) 1999 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)1182-1192
Number of pages11
JournalFree Radical Biology and Medicine
Issue number11-12
StatePublished - 1999


  • Antioxidant vitamins
  • Breath ethane
  • Free radical
  • Ionizing radiation
  • Reactive oxygen species
  • Reperfusion injury
  • Smoking

ASJC Scopus subject areas

  • Biochemistry
  • Physiology (medical)


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