TY - JOUR
T1 - Climatic, temporal, and geographic characteristics of respiratory syncytial virus disease in a tropical island population
AU - Omer, S. B.
AU - Sutanto, A.
AU - Sarwo, H.
AU - Linehan, M.
AU - Djelantik, I. G.G.
AU - Mercer, D.
AU - Moniaga, V.
AU - Moulton, L. H.
AU - Widjaya, A.
AU - Muljati, P.
AU - Gessner, B. D.
AU - Steinhoff, M. C.
PY - 2008
Y1 - 2008
N2 - Respiratory syncytial virus (RSV) is an important cause of morbidity in children worldwide, although data from equatorial regions are limited. We analysed climatic, spatial, and temporal data for children presenting to hospitals in Lombok island, Indonesia with clinical pneumonia. During the study period, 2878 children presented and 741 RSV cases were identified. In multivariate analysis with an 8-day lag, occurrence of rain was associated with 64% higher incidence of RSV disease [incidence rate ratio (IRR) 1·64, 95% confidence interval (CI) 1·13-2·38]. A 1% rise in mean relative humidity and 1°C increase in mean air temperature was associated with a 6% (IRR 1·06, 95% CI 1·03-1·10) and 44% (IRR 1·44, 95% CI 1·24-1·66) increase in RSV cases, respectively. Four statistically significant local clusters of RSV pneumonia were identified within the annual island-wide epidemics. This study demonstrates statistical association of monsoon-associated weather in equatorial Indonesia with RSV. Moreover, within the island-wide epidemics, localized RSV outbreaks suggest local factors influence RSV disease. © 2008
AB - Respiratory syncytial virus (RSV) is an important cause of morbidity in children worldwide, although data from equatorial regions are limited. We analysed climatic, spatial, and temporal data for children presenting to hospitals in Lombok island, Indonesia with clinical pneumonia. During the study period, 2878 children presented and 741 RSV cases were identified. In multivariate analysis with an 8-day lag, occurrence of rain was associated with 64% higher incidence of RSV disease [incidence rate ratio (IRR) 1·64, 95% confidence interval (CI) 1·13-2·38]. A 1% rise in mean relative humidity and 1°C increase in mean air temperature was associated with a 6% (IRR 1·06, 95% CI 1·03-1·10) and 44% (IRR 1·44, 95% CI 1·24-1·66) increase in RSV cases, respectively. Four statistically significant local clusters of RSV pneumonia were identified within the annual island-wide epidemics. This study demonstrates statistical association of monsoon-associated weather in equatorial Indonesia with RSV. Moreover, within the island-wide epidemics, localized RSV outbreaks suggest local factors influence RSV disease. © 2008
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U2 - 10.1017/S0950268807000015
DO - 10.1017/S0950268807000015
M3 - Article
C2 - 18177515
AN - SCOPUS:52249110903
SN - 0950-2688
VL - 136
SP - 1319
EP - 1327
JO - Epidemiology and infection
JF - Epidemiology and infection
IS - 10
ER -