Class II transactivator suppresses transcription of thyroid-specific genes

Atsumi Mori-Aoki; Michelle Pietrarelli; Minoru Nakazato; Patrizio Caturegli; Leonard D. Kohn; Koichi Suzuki

doi:10.1006/bbrc.2000.3769

Class II transactivator suppresses transcription of thyroid-specific genes

Atsumi Mori-Aoki, Michelle Pietrarelli, Minoru Nakazato, Patrizio Caturegli, Leonard D. Kohn, Koichi Suzuki

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

Original language	English (US)
Pages (from-to)	58-62
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	278
Issue number	1
DOIs	https://doi.org/10.1006/bbrc.2000.3769
State	Published - Nov 11 2000

Keywords

Antigen presentation
Autoimmunity
Gene regulation
MHC
Thyroid
Transcription factors

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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10.1006/bbrc.2000.3769

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abstract = "Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.",

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AU - Mori-Aoki, Atsumi

AU - Pietrarelli, Michelle

AU - Nakazato, Minoru

AU - Caturegli, Patrizio

AU - Kohn, Leonard D.

AU - Suzuki, Koichi

PY - 2000/11/11

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AB - Class II transactivator (CIITA) is the master regulator of MHC class II genes, and mediates their induction by interferon gamma (IFNγ). To study the role of CIITA in modulating the expression of thyroid-specific genes, we cloned the full-length rat CIITA and use it to transfect a rat thyroid cell line. We found that only one type of CIITA, type IV, is induced in thyroid cells upon IFNγ stimulation, and that CIITA is capable not only of inducing the expression of MHC genes in the thyroid, but also of differentially suppressing the expression of thyroid-specific genes. These findings suggest new avenues for the development of thyroid autoimmune diseases. (C) 2000 Academic Press.

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Class II transactivator suppresses transcription of thyroid-specific genes

Abstract

Keywords

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