Clarithromycin extended-release in community-acquired respiratory tract infections

Kathy N. Williams, William R. Bishai

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Clarithromycin extended-release (ER) is a second-generation macrolide with bactericidal activity against a broad group of pathogens. It allows for convenient once-daily dosing (2 × 500 mg/day), and has less severe adverse effects than the immediate-release (IR) formulation of the drug, which may result in improved patient compliance. Clarithromycin ER has been approved for the treatment of community-acquired pneumonia, acute maxillary sinusitis and acute bacterial exacerbation of chronic bronchitis. In comparison to the IR formulation, clarithromycin ER demonstrates prolonged absorption from the gastrointestinal tract, allowing for once-daily dosing with improved gastrointestinal tolerability. Various double-blind, randomised clinical trials and group studies have found clarithromycin ER to be an efficacious treatment option, comparable with clarithromycin IR, or its other competitors.

Original languageEnglish (US)
Pages (from-to)2867-2876
Number of pages10
JournalExpert opinion on pharmacotherapy
Issue number16
StatePublished - Dec 2005


  • Acute bacterial sinusitis
  • Acute exacerbation
  • Chronic bronchitis
  • Community-acquired pneumonia
  • Macrolides

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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