@article{f04bf5ab80b74c398c9e3c87f6162954,
title = "CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells",
abstract = "Conjugated linoleic acid (CLA) has been shown to activate the nuclear receptor PPAR-γ and modulate metabolic and immune functions. Despite the worldwide use of CLA dietary supplementation, strong scientific evidence for its proposed beneficial actions are missing. We found that CLA-supplemented diet reduced mucosal damage and inflammatory infiltrate in the dextran sodium sulfate (DSS)-induced colitis model. Conditional deletion of PPAR-γ in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-γ-dependent mechanism mediated by macrophages. However, CLA supplementation significantly worsened colorectal tumor formation induced by azoxymethane and DSS by inducing macrophage and T-cell-producing TGF-β via PPAR-γ activation. Accordingly, either macrophage-specific deletion of PPAR-γ or in vivo neutralization of latency-associated peptide (LAP, a membrane-bound TGF-β)-expressing cells abrogated the protumorigenic effect of CLA. Thus, the anti-inflammatory properties of CLA are associated with prevention of colitis but also with development of colorectal cancer.",
author = "Moreira, {T. G.} and Horta, {L. S.} and Gomes-Santos, {A. C.} and Oliveira, {R. P.} and Queiroz, {N. M.G.P.} and D. Mangani and B. Daniel and Vieira, {A. T.} and S. Liu and Rodrigues, {A. M.} and Gomes, {D. A.} and G. Gabriely and E. Ferreira and Weiner, {H. L.} and Rezende, {R. M.} and L. Nagy and Faria, {A. M.C.}",
note = "Funding Information: We would like to acknowledge Marie Curie fellowship program, and Nuclear Receptor-network EU-funded project for supporting collaboration projects. We are thankful to BASF company for kindly provide Tonalin{\textregistered}, to Dr. Dezs{\H o} Bal{\'a}zs from Pathology Department from Debrecen University, Hungary for the kind help with pathology discussions and slides manufacture. We are also grateful to Dr. Vany Ferraz from Chemistry Department of UFMG, Brazil for providing CG analysis of CLA diet, to Dr. Denise Carmona (UFMG, Brazil), and Dr. Claudia Martins Carneiro (UFOP, Brazil) for discussion and pathological analysis. This study had financial support from Conselho Nacional de Desenvolvimento Cient{\'i}fico e Tecnol{\'o}gico, Brazil (CNPq) and Funda{\c c}{\~a}o de Amparo a Pesquisa do Estado de Minas Gerais, Brazil (FAPEMIG). Publisher Copyright: {\textcopyright} 2018, Society for Mucosal Immunology.",
year = "2019",
month = jan,
day = "1",
doi = "10.1038/s41385-018-0090-8",
language = "English (US)",
volume = "12",
pages = "188--199",
journal = "Mucosal Immunology",
issn = "1933-0219",
publisher = "Elsevier B.V.",
number = "1",
}