Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma

Ju Dong Yang; Michael B. Campion; Minetta C. Liu; Roongruedee Chaiteerakij; Nasra H. Giama; Hager Ahmed Mohammed; Xiaodan Zhang; Chunling Hu; Victoria L. Campion; Jin Jen; Sudhakar K. Venkatesh; Kevin C. Halling; Benjamin R. Kipp; Lewis R. Roberts

doi:10.1002/hep.27944

Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma

Ju Dong Yang, Michael B. Campion, Minetta C. Liu, Roongruedee Chaiteerakij, Nasra H. Giama, Hager Ahmed Mohammed, Xiaodan Zhang, Chunling Hu, Victoria L. Campion, Jin Jen, Sudhakar K. Venkatesh, Kevin C. Halling, Benjamin R. Kipp, Lewis R. Roberts

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44 Scopus citations

Abstract

Circulating tumor cells (CTCs) in blood are associated with poor survival of patients with breast, prostate, or colon cancer. We hypothesized that CTCs are associated with poor survival of patients with cholangiocarcinoma (CCA). Eighty-eight patients with CCA were prospectively enrolled at Mayo Clinic Rochester between June 2010 and September 2014. The CellSearch system by Veridex was used for detection of CTCs in peripheral blood. Associations between CTC, patient and tumor characteristics, and survival were examined using the Cox's proportional hazards model. Fifteen patients (17%) were positive for CTC ≥2 and 8 patients (9%) for CTC ≥5. CTCs were associated with tumor extent. CTC ≥2 (hazard ratio [HR]: 2.5; 95% confidence interval [CI]: 1.1-5.4; P=0.02) and CTC ≥5 (HR, 4.1; 95% CI: 1.4-10.8; P=0.01) were both independent predictors of survival. In subgroup analyses, CTC ≥2 (HR, 8.2; 95% CI: 1.8-57.5; P

Original language	English (US)
Pages (from-to)	148-158
Number of pages	11
Journal	Hepatology
Volume	63
Issue number	1
DOIs	https://doi.org/10.1002/hep.27944
State	Published - Jan 1 2016
Externally published	Yes

ASJC Scopus subject areas

Hepatology

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Yang, J. D., Campion, M. B., Liu, M. C., Chaiteerakij, R., Giama, N. H., Ahmed Mohammed, H., Zhang, X., Hu, C., Campion, V. L., Jen, J., Venkatesh, S. K., Halling, K. C., Kipp, B. R., & Roberts, L. R. (2016). Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma. Hepatology, 63(1), 148-158. https://doi.org/10.1002/hep.27944

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title = "Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma",

abstract = "Circulating tumor cells (CTCs) in blood are associated with poor survival of patients with breast, prostate, or colon cancer. We hypothesized that CTCs are associated with poor survival of patients with cholangiocarcinoma (CCA). Eighty-eight patients with CCA were prospectively enrolled at Mayo Clinic Rochester between June 2010 and September 2014. The CellSearch system by Veridex was used for detection of CTCs in peripheral blood. Associations between CTC, patient and tumor characteristics, and survival were examined using the Cox's proportional hazards model. Fifteen patients (17%) were positive for CTC ≥2 and 8 patients (9%) for CTC ≥5. CTCs were associated with tumor extent. CTC ≥2 (hazard ratio [HR]: 2.5; 95% confidence interval [CI]: 1.1-5.4; P=0.02) and CTC ≥5 (HR, 4.1; 95% CI: 1.4-10.8; P=0.01) were both independent predictors of survival. In subgroup analyses, CTC ≥2 (HR, 8.2; 95% CI: 1.8-57.5; P",

author = "Yang, {Ju Dong} and Campion, {Michael B.} and Liu, {Minetta C.} and Roongruedee Chaiteerakij and Giama, {Nasra H.} and {Ahmed Mohammed}, Hager and Xiaodan Zhang and Chunling Hu and Campion, {Victoria L.} and Jin Jen and Venkatesh, {Sudhakar K.} and Halling, {Kevin C.} and Kipp, {Benjamin R.} and Roberts, {Lewis R.}",

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doi = "10.1002/hep.27944",

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AU - Yang, Ju Dong

AU - Campion, Michael B.

AU - Liu, Minetta C.

AU - Chaiteerakij, Roongruedee

AU - Giama, Nasra H.

AU - Ahmed Mohammed, Hager

AU - Zhang, Xiaodan

AU - Hu, Chunling

AU - Campion, Victoria L.

AU - Jen, Jin

AU - Venkatesh, Sudhakar K.

AU - Halling, Kevin C.

AU - Kipp, Benjamin R.

AU - Roberts, Lewis R.

PY - 2016/1/1

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N2 - Circulating tumor cells (CTCs) in blood are associated with poor survival of patients with breast, prostate, or colon cancer. We hypothesized that CTCs are associated with poor survival of patients with cholangiocarcinoma (CCA). Eighty-eight patients with CCA were prospectively enrolled at Mayo Clinic Rochester between June 2010 and September 2014. The CellSearch system by Veridex was used for detection of CTCs in peripheral blood. Associations between CTC, patient and tumor characteristics, and survival were examined using the Cox's proportional hazards model. Fifteen patients (17%) were positive for CTC ≥2 and 8 patients (9%) for CTC ≥5. CTCs were associated with tumor extent. CTC ≥2 (hazard ratio [HR]: 2.5; 95% confidence interval [CI]: 1.1-5.4; P=0.02) and CTC ≥5 (HR, 4.1; 95% CI: 1.4-10.8; P=0.01) were both independent predictors of survival. In subgroup analyses, CTC ≥2 (HR, 8.2; 95% CI: 1.8-57.5; P

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Circulating tumor cells are associated with poor overall survival in patients with cholangiocarcinoma

Abstract

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