Circulating levels of gonadotropins before and after prostate ablation in cancer patients

George Yu, George Yu, Charles Mylander, Abdulmaged Traish, Thomas Jarrett

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The prostate gland synthesizes a host of hormones., prostaglandins and growth factors. It is not clear if such biochemical factors modulate the hypothalamic/pituitary (H-P) gonadal axis. Aim: To determine the influence of the prostate gland on the hypothalamic-pituitary axis feedback system and changes in circulating hormone levels before and after cryoablation of the entire prostate. Methods: In 37 consecutive patients with localized prostate cancer who underwent total cryoablation we investigated the circulating levels of testosterone., estradiol, progesterone., sex hormone binding globulin (SHBG) lute-inizing hormone (LH), follicle stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), prolactin., insulin-like growth factor-1(IGF-1) and prostatic specific antigen (PSA) from 3 years prior to diagnosis to 3 years after initiating treatment. Results: The levels of LH and FSH were significantly elevated in most patients up to 3 years after surgery. No significant changes were observed for the other hormones., with a decrease in PSA as expected. Conclusion: LH and FSH levels rise after ablation of the prostate gland and the levels remain high for up to 3 years after surgery., which suggests that the prostate gland may influence the H-P feedback axis.

Original languageEnglish (US)
Pages (from-to)355-362
Number of pages8
JournalHormone Molecular Biology and Clinical Investigation
Volume11
Issue number3
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • follicle stimulating hormone (FSH)
  • gonado-tropins
  • luteinizing hormone (LH)
  • prostate ablation
  • prostate cancer

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Endocrinology

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