Abstract
Background: The prostate gland synthesizes a host of hormones., prostaglandins and growth factors. It is not clear if such biochemical factors modulate the hypothalamic/pituitary (H-P) gonadal axis. Aim: To determine the influence of the prostate gland on the hypothalamic-pituitary axis feedback system and changes in circulating hormone levels before and after cryoablation of the entire prostate. Methods: In 37 consecutive patients with localized prostate cancer who underwent total cryoablation we investigated the circulating levels of testosterone., estradiol, progesterone., sex hormone binding globulin (SHBG) lute-inizing hormone (LH), follicle stimulating hormone (FSH), dehydroepiandrosterone sulfate (DHEAS), prolactin., insulin-like growth factor-1(IGF-1) and prostatic specific antigen (PSA) from 3 years prior to diagnosis to 3 years after initiating treatment. Results: The levels of LH and FSH were significantly elevated in most patients up to 3 years after surgery. No significant changes were observed for the other hormones., with a decrease in PSA as expected. Conclusion: LH and FSH levels rise after ablation of the prostate gland and the levels remain high for up to 3 years after surgery., which suggests that the prostate gland may influence the H-P feedback axis.
Original language | English (US) |
---|---|
Pages (from-to) | 355-362 |
Number of pages | 8 |
Journal | Hormone Molecular Biology and Clinical Investigation |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - 2012 |
Externally published | Yes |
Keywords
- follicle stimulating hormone (FSH)
- gonado-tropins
- luteinizing hormone (LH)
- prostate ablation
- prostate cancer
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Endocrinology