Circulating levels of carboxy-methyl-lysine (CML) are associated with hip fracture risk: The cardiovascular health study

Joshua I. Barzilay; Petra Bůžková; Susan J. Zieman; Jorge R. Kizer; Luc Djoussé; Joachim H. Ix; Russell P. Tracy; David S. Siscovick; Jane A. Cauley; Kenneth J. Mukamal

doi:10.1002/jbmr.2123

Circulating levels of carboxy-methyl-lysine (CML) are associated with hip fracture risk: The cardiovascular health study

Joshua I. Barzilay, Petra Bůžková, Susan J. Zieman, Jorge R. Kizer, Luc Djoussé, Joachim H. Ix, Russell P. Tracy, David S. Siscovick, Jane A. Cauley, Kenneth J. Mukamal

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Advanced glycation end products (AGE) in bone tissue are associated with impaired biomechanical properties and increased fracture risk. Here we examine whether serum levels of the AGE carboxy-methyl-lysine (CML) are associated with risk of hip fracture. We followed 3373 participants from the Cardiovascular Health Study (age 78 years; range, 68-102 years; 39.8% male) for a median of 9.22 years (range, 0.01-12.07 years). Rates of incident hip fracture were calculated by quartiles of baseline CML levels, and hazard ratios were adjusted for covariates associated with hip fracture risk. A subcohort of 1315 participants had bone mineral density (BMD) measurement. There were 348 hip fractures during follow-up, with incidence rates of hip fracture by CML quartiles of 0.94, 1.34, 1.18, and 1.69 per 100 participant-years. The unadjusted hazard ratio of hip fracture increased with each 1 SD increase (189ng/mL) of CML level (hazard ratio, 1.27; 95% confidence interval [CI], 1.16-1.40]; p

Original language	English (US)
Pages (from-to)	1061-1066
Number of pages	6
Journal	Journal of Bone and Mineral Research
Volume	29
Issue number	5
DOIs	https://doi.org/10.1002/jbmr.2123
State	Published - 2014
Externally published	Yes

Keywords

bone mineral density
bone quality
carboxy-methyl-lysine
cardiovascular health study
hip fracture risk

ASJC Scopus subject areas

Orthopedics and Sports Medicine
Endocrinology, Diabetes and Metabolism
Medicine(all)

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10.1002/jbmr.2123

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Barzilay, J. I., Bůžková, P., Zieman, S. J., Kizer, J. R., Djoussé, L., Ix, J. H., Tracy, R. P., Siscovick, D. S., Cauley, J. A., & Mukamal, K. J. (2014). Circulating levels of carboxy-methyl-lysine (CML) are associated with hip fracture risk: The cardiovascular health study. Journal of Bone and Mineral Research, 29(5), 1061-1066. https://doi.org/10.1002/jbmr.2123

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abstract = "Advanced glycation end products (AGE) in bone tissue are associated with impaired biomechanical properties and increased fracture risk. Here we examine whether serum levels of the AGE carboxy-methyl-lysine (CML) are associated with risk of hip fracture. We followed 3373 participants from the Cardiovascular Health Study (age 78 years; range, 68-102 years; 39.8% male) for a median of 9.22 years (range, 0.01-12.07 years). Rates of incident hip fracture were calculated by quartiles of baseline CML levels, and hazard ratios were adjusted for covariates associated with hip fracture risk. A subcohort of 1315 participants had bone mineral density (BMD) measurement. There were 348 hip fractures during follow-up, with incidence rates of hip fracture by CML quartiles of 0.94, 1.34, 1.18, and 1.69 per 100 participant-years. The unadjusted hazard ratio of hip fracture increased with each 1 SD increase (189ng/mL) of CML level (hazard ratio, 1.27; 95% confidence interval [CI], 1.16-1.40]; p",

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Circulating levels of carboxy-methyl-lysine (CML) are associated with hip fracture risk: The cardiovascular health study

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