Circulating 25-hydroxyvitamin D and risk of pancreatic cancer: Cohort Consortium Vitamin D Pooling Project of Rarer Cancers

Rachael Z. Stolzenberg-Solomon, Eric J. Jacobs, Alan A. Arslan, Dai Qi, Alpa V. Patel, Kathy J. Helzlsouer, Stephanie J. Weinstein, Marjorie L. McCullough, Mark P. Purdue, Xiao Ou Shu, Kirk Snyder, Jarmo Virtamo, Lynn R. Wilkins, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Demetrius Albanes, Qiuyin Cai, Chinonye Harvey, Richard HayesSandra Clipp, Ronald L. Horst, Lonn Irish, Karen Koenig, Loic Le Marchand, Laurence N. Kolonel

Research output: Contribution to journalArticlepeer-review

174 Scopus citations


Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (≥100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.

Original languageEnglish (US)
Pages (from-to)81-93
Number of pages13
JournalAmerican journal of epidemiology
Issue number1
StatePublished - 2010
Externally publishedYes


  • Case-control studies
  • Cohort studies
  • Pancreatic neoplasms
  • Prospective studies
  • Vitamin D

ASJC Scopus subject areas

  • Epidemiology


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