TY - JOUR
T1 - Circulating 25-hydroxyvitamin D and risk of pancreatic cancer
T2 - Cohort Consortium Vitamin D Pooling Project of Rarer Cancers
AU - Stolzenberg-Solomon, Rachael Z.
AU - Jacobs, Eric J.
AU - Arslan, Alan A.
AU - Qi, Dai
AU - Patel, Alpa V.
AU - Helzlsouer, Kathy J.
AU - Weinstein, Stephanie J.
AU - McCullough, Marjorie L.
AU - Purdue, Mark P.
AU - Shu, Xiao Ou
AU - Snyder, Kirk
AU - Virtamo, Jarmo
AU - Wilkins, Lynn R.
AU - Yu, Kai
AU - Zeleniuch-Jacquotte, Anne
AU - Zheng, Wei
AU - Albanes, Demetrius
AU - Cai, Qiuyin
AU - Harvey, Chinonye
AU - Hayes, Richard
AU - Clipp, Sandra
AU - Horst, Ronald L.
AU - Irish, Lonn
AU - Koenig, Karen
AU - Le Marchand, Loic
AU - Kolonel, Laurence N.
PY - 2010
Y1 - 2010
N2 - Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (≥100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.
AB - Results from epidemiologic studies examining pancreatic cancer risk and vitamin D intake or 25-hydroxyvitamin D (25(OH)D) concentrations (the best indicator of vitamin D derived from diet and sun) have been inconsistent. Therefore, the authors conducted a pooled nested case-control study of participants from 8 cohorts within the Cohort Consortium Vitamin D Pooling Project of Rarer Cancers (VDPP) (1974-2006) to evaluate whether prediagnostic circulating 25(OH)D concentrations were associated with the development of pancreatic cancer. In total, 952 incident pancreatic adenocarcinoma cases occurred among participants (median follow-up, 6.5 years). Controls (n = 1,333) were matched to each case by cohort, age, sex, race/ethnicity, date of blood draw, and follow-up time. Conditional logistic regression analysis was used to calculate smoking-, body mass index-, and diabetes-adjusted odds ratios and 95% confidence intervals for pancreatic cancer. Clinically relevant 25(OH)D cutpoints were compared with a referent category of 50-<75 nmol/L. No significant associations were observed for participants with lower 25(OH)D status. However, a high 25(OH)D concentration (≥100 nmol/L) was associated with a statistically significant 2-fold increase in pancreatic cancer risk overall (odds ratio = 2.12, 95% confidence interval: 1.23, 3.64). Given this result, recommendations to increase vitamin D concentrations in healthy persons for the prevention of cancer should be carefully considered.
KW - Case-control studies
KW - Cohort studies
KW - Pancreatic neoplasms
KW - Prospective studies
KW - Vitamin D
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U2 - 10.1093/aje/kwq120
DO - 10.1093/aje/kwq120
M3 - Article
C2 - 20562185
AN - SCOPUS:77956919944
SN - 0002-9262
VL - 172
SP - 81
EP - 93
JO - American journal of epidemiology
JF - American journal of epidemiology
IS - 1
ER -