CIMPle origin for promoter hypermethylation in colorectal cancer?

Research output: Contribution to journalShort surveypeer-review

22 Scopus citations


The proposal that a distinct subset of colorectal cancers show a marked propensity for promoter CpG island DNA methylation and associated gene silencing has been hotly debated. A new study takes an unbiased approach and not only strongly concludes that a CpG island methylator phenotype exists, but also offers new markers to define a concept that could teach much about the origins of cancer.

Original languageEnglish (US)
Pages (from-to)738-740
Number of pages3
JournalNature genetics
Issue number7
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Genetics


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