Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Marisol Cano; Rajesh Thimmalappula; Masashi Fujihara; Norihiro Nagai; Michael Sporn; Ai Ling Wang; Arthur H. Neufeld; Shyam Biswal; James T. Handa

doi:10.1016/j.visres.2009.08.018

Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

Marisol Cano, Rajesh Thimmalappula, Masashi Fujihara, Norihiro Nagai, Michael Sporn, Ai Ling Wang, Arthur H. Neufeld, Shyam Biswal, James T. Handa

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.

Original language	English (US)
Pages (from-to)	652-664
Number of pages	13
Journal	Vision Research
Volume	50
Issue number	7
DOIs	https://doi.org/10.1016/j.visres.2009.08.018
State	Published - Mar 2010

Keywords

Age-related Macular Degeneration
Cigarette smoking
Nrf2
Oxidative stress
Retinal pigmented epithelium

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/j.visres.2009.08.018

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title = "Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration",

abstract = "Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.",

keywords = "Age-related Macular Degeneration, Cigarette smoking, Nrf2, Oxidative stress, Retinal pigmented epithelium",

author = "Marisol Cano and Rajesh Thimmalappula and Masashi Fujihara and Norihiro Nagai and Michael Sporn and Wang, {Ai Ling} and Neufeld, {Arthur H.} and Shyam Biswal and Handa, {James T.}",

note = "Funding Information: This work is supported by Grants EY019904 (JTH), The Robert Bond Welch Professorship (JTH); NIH HL081205 (SB), NIH/NHLBI SCCOR Grant P50HL084945 (SB), Clinical Innovator award from FAMRI (SB); NIH Grant CA-78814 (MS), and a grant from Reata Pharmaceuticals (MS); and generous gifts from Ric and Sandy Forsythe, the Kwok family, the Merlau family, and Aleda Wright, and Research to Prevent Blindness to Wilmer Eye Institute, Forsythe Foundation (AHN), and unrestricted grants from Research to Prevent Blindness (Northwestern University).",

year = "2010",

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doi = "10.1016/j.visres.2009.08.018",

language = "English (US)",

volume = "50",

pages = "652--664",

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AU - Cano, Marisol

AU - Thimmalappula, Rajesh

AU - Fujihara, Masashi

AU - Nagai, Norihiro

AU - Sporn, Michael

AU - Wang, Ai Ling

AU - Neufeld, Arthur H.

AU - Biswal, Shyam

AU - Handa, James T.

N1 - Funding Information: This work is supported by Grants EY019904 (JTH), The Robert Bond Welch Professorship (JTH); NIH HL081205 (SB), NIH/NHLBI SCCOR Grant P50HL084945 (SB), Clinical Innovator award from FAMRI (SB); NIH Grant CA-78814 (MS), and a grant from Reata Pharmaceuticals (MS); and generous gifts from Ric and Sandy Forsythe, the Kwok family, the Merlau family, and Aleda Wright, and Research to Prevent Blindness to Wilmer Eye Institute, Forsythe Foundation (AHN), and unrestricted grants from Research to Prevent Blindness (Northwestern University).

PY - 2010/3

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N2 - Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.

AB - Age-related Macular Degeneration (AMD) is the leading cause of blindness among the elderly. While excellent treatment has emerged for neovascular disease, treatment for early AMD is lacking due to an incomplete understanding of the early molecular events. Cigarette smoking is the strongest epidemiologic risk factor, yet we do not understand how smoking contributes to AMD. Smoking related oxidative damage during the early phases of AMD may play an important role. This review explores how cigarette smoking and oxidative stress to the retinal pigmented epithelium (RPE) might contribute to AMD, and how the transcription factor Nrf2 can activate a cytoprotective response.

KW - Age-related Macular Degeneration

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KW - Oxidative stress

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Cigarette smoking, oxidative stress, the anti-oxidant response through Nrf2 signaling, and Age-related Macular Degeneration

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Keywords

ASJC Scopus subject areas

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