Cigarette smoking and subjective response: Effects of d-amphetamine

Jack E. Henningfield, Roland R. Griffiths

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


The effects of oral d-amphetamine on cigarette smoking and subjective responses were determined in eight adults who smoked cigarettes. Subjects were tested each day in rooms that provided a comfortable, natural environment while cigarette-smoking behavior was automatically monitored. Each subject served as his own control and was tested at four d-amphetamine dose levels (0, 5, 15, 25 mg) that were scheduled according to five randomized block sequences. d-Amphetamine induced dose-related increases in the number of cigarettes smoked, total puffs, weight of tobacco consumed, expired air carbon monoxide levels, subject-rated satisfaction derived from smoking, and scores on scales of the Addiction Research Center Inventory (ARCI). As measures of drug effects, both the behavioral measures of smoking and the ARCI scales were sensitive when the data from the subjects were grouped and tested for statistical significance. Behavioral measures, however, were more sensitive than the ARCI scales when a within-subject analysis was performed.

Original languageEnglish (US)
Pages (from-to)497-505
Number of pages9
JournalClinical pharmacology and therapeutics
Issue number4
StatePublished - Oct 1981

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)


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