Cigarette smokers self-administer intravenous nicotine

Jack E. Henningfield, Katsumasa Miyasato, Donald R. Jasinski

Research output: Contribution to journalArticlepeer-review

124 Scopus citations


Human volunteers who smoked cigarettes were given the opportunity to press a lever that resulted in intravenous injections of saline or nicotine. Nicotine injections were taken in orderly patterns that were related to unit dose, whereas patterns of saline injections varied widely. Furthermore, the volunteers reported that nicotine produced subjective effects similar to those produced by administration of abused drugs such as morphine or cocaine.

Original languageEnglish (US)
Pages (from-to)887-890
Number of pages4
JournalPharmacology Biochemistry and Behavior
Issue number5
StatePublished - 1983
Externally publishedYes


  • Cigarette smokers
  • Drug abuse
  • Human studies
  • Nicotine
  • Self-administration

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology


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