TY - JOUR
T1 - Chronic wound repair and healing in older adults
T2 - Current status and future research
AU - Gould, Lisa
AU - Abadir, Peter
AU - Brem, Harold
AU - Carter, Marissa
AU - Conner-Kerr, Teresa
AU - Davidson, Jeff
AU - Dipietro, Luisa
AU - Falanga, Vincent
AU - Fife, Caroline
AU - Gardner, Sue
AU - Grice, Elizabeth
AU - Harmon, John
AU - Hazzard, William R.
AU - High, Kevin P.
AU - Houghton, Pamela
AU - Jacobson, Nasreen
AU - Kirsner, Robert S.
AU - Kovacs, Elizabeth J.
AU - Margolis, David
AU - McFarland Horne, Frances
AU - Reed, May J.
AU - Sullivan, Dennis H.
AU - Thom, Stephen
AU - Tomic-Canic, Marjana
AU - Walston, Jeremy
AU - Whitney, Joanne
AU - Williams, John
AU - Zieman, Susan
AU - Schmader, Kenneth
N1 - Publisher Copyright:
© 2014 by the Wound Healing Society.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this population. It is well established that wound healing slows with age. However, the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The impact of age and accompanying multi-morbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables, lack of standardization in data collection, and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The Association of Specialty Professors, in conjunction with the National Institute on Aging and the Wound Healing Society, held a workshop, summarized in this paper, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify key research questions to guide future study of age-associated changes in chronic wound healing.
AB - The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this population. It is well established that wound healing slows with age. However, the basic biology underlying chronic wounds and the influence of age-associated changes on wound healing are poorly understood. Most studies have used in vitro approaches and various animal models, but observed changes translate poorly to human healing conditions. The impact of age and accompanying multi-morbidity on the effectiveness of existing and emerging treatment approaches for chronic wounds is also unknown, and older adults tend to be excluded from randomized clinical trials. Poorly defined outcomes and variables, lack of standardization in data collection, and variations in the definition, measurement, and treatment of wounds also hamper clinical studies. The Association of Specialty Professors, in conjunction with the National Institute on Aging and the Wound Healing Society, held a workshop, summarized in this paper, to explore the current state of knowledge and research challenges, engage investigators across disciplines, and identify key research questions to guide future study of age-associated changes in chronic wound healing.
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U2 - 10.1111/wrr.12245
DO - 10.1111/wrr.12245
M3 - Review article
C2 - 25486905
AN - SCOPUS:84928585547
SN - 1067-1927
VL - 23
SP - 1
EP - 13
JO - Wound Repair and Regeneration
JF - Wound Repair and Regeneration
IS - 1
ER -