Chronic renal insufficiency cohort study (CRIC): Overview and summary of selected findings

Matthew Denker; Suzanne Boyle; Amanda H. Anderson; Lawrence J. Appel; Jing Chen; Jeffrey C. Fink; John Flack; Alan S. Go; Edward Horwitz; Chi Yuan Hsu; John W. Kusek; James P. Lash; Sankar Navaneethan; Akinlolu O. Ojo; Mahboob Rahman; Susan P. Steigerwalt; Raymond R. Townsend; Harold I. Feldman

doi:10.2215/CJN.04260415

Chronic renal insufficiency cohort study (CRIC): Overview and summary of selected findings

Matthew Denker, Suzanne Boyle, Amanda H. Anderson, Lawrence J. Appel, Jing Chen, Jeffrey C. Fink, John Flack, Alan S. Go, Edward Horwitz, Chi Yuan Hsu, John W. Kusek, James P. Lash, Sankar Navaneethan, Akinlolu O. Ojo, Mahboob Rahman, Susan P. Steigerwalt, Raymond R. Townsend, Harold I. Feldman

School of Medicine

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

The Chronic Renal Insufficiency Cohort (CRIC) Study is a United States multicenter, prospective study of racially and ethnically diverse patients with CKD. Although the original aims of the study were to identify novel predictors of CKD progression and to elucidate the risk and manifestations of cardiovascular disease among nearly 4000 individuals with CKD, the CRIC Study has evolved into a national resource for investigation of a broad spectrumof CKD-related topics. The study has produced >90 published scientific articles, promotedmany young investigative careers in nephrology, and fostered international collaborations focused on understanding the global burden of CKD. The third phase of the CRIC Study will complete enrollment of 1500 additional study participants in 2015 and is designed to answer questions regarding morbidity and mortality in mild-to-moderate CKD and to assess the burden of CKD in older persons. This review highlights some of the salient findings of the CRIC Study in the areas of race and ethnicity, CKD progression, CKD and cognition, and cardiovascular disease outcomes; it also outlines the ongoing and forthcoming opportunities for the global nephrology community to enhance its understanding of CKD and related complications through the study.

Original language	English (US)
Pages (from-to)	2073-2083
Number of pages	11
Journal	Clinical Journal of the American Society of Nephrology
Volume	10
Issue number	11
DOIs	https://doi.org/10.2215/CJN.04260415
State	Published - Nov 6 2015

ASJC Scopus subject areas

Epidemiology
Critical Care and Intensive Care Medicine
Nephrology
Transplantation

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Denker, M., Boyle, S., Anderson, A. H., Appel, L. J., Chen, J., Fink, J. C., Flack, J., Go, A. S., Horwitz, E., Hsu, C. Y., Kusek, J. W., Lash, J. P., Navaneethan, S., Ojo, A. O., Rahman, M., Steigerwalt, S. P., Townsend, R. R., & Feldman, H. I. (2015). Chronic renal insufficiency cohort study (CRIC): Overview and summary of selected findings. Clinical Journal of the American Society of Nephrology, 10(11), 2073-2083. https://doi.org/10.2215/CJN.04260415

Denker, M, Boyle, S, Anderson, AH, Appel, LJ, Chen, J, Fink, JC, Flack, J, Go, AS, Horwitz, E, Hsu, CY, Kusek, JW, Lash, JP, Navaneethan, S, Ojo, AO, Rahman, M, Steigerwalt, SP, Townsend, RR & Feldman, HI 2015, 'Chronic renal insufficiency cohort study (CRIC): Overview and summary of selected findings', Clinical Journal of the American Society of Nephrology, vol. 10, no. 11, pp. 2073-2083. https://doi.org/10.2215/CJN.04260415

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abstract = "The Chronic Renal Insufficiency Cohort (CRIC) Study is a United States multicenter, prospective study of racially and ethnically diverse patients with CKD. Although the original aims of the study were to identify novel predictors of CKD progression and to elucidate the risk and manifestations of cardiovascular disease among nearly 4000 individuals with CKD, the CRIC Study has evolved into a national resource for investigation of a broad spectrumof CKD-related topics. The study has produced >90 published scientific articles, promotedmany young investigative careers in nephrology, and fostered international collaborations focused on understanding the global burden of CKD. The third phase of the CRIC Study will complete enrollment of 1500 additional study participants in 2015 and is designed to answer questions regarding morbidity and mortality in mild-to-moderate CKD and to assess the burden of CKD in older persons. This review highlights some of the salient findings of the CRIC Study in the areas of race and ethnicity, CKD progression, CKD and cognition, and cardiovascular disease outcomes; it also outlines the ongoing and forthcoming opportunities for the global nephrology community to enhance its understanding of CKD and related complications through the study.",

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Chronic renal insufficiency cohort study (CRIC): Overview and summary of selected findings

Abstract

ASJC Scopus subject areas

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