Chronic renal insufficiency cohort study (CRIC): Overview and summary of selected findings

Matthew Denker, Suzanne Boyle, Amanda H. Anderson, Lawrence J. Appel, Jing Chen, Jeffrey C. Fink, John Flack, Alan S. Go, Edward Horwitz, Chi Yuan Hsu, John W. Kusek, James P. Lash, Sankar Navaneethan, Akinlolu O. Ojo, Mahboob Rahman, Susan P. Steigerwalt, Raymond R. Townsend, Harold I. Feldman

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


The Chronic Renal Insufficiency Cohort (CRIC) Study is a United States multicenter, prospective study of racially and ethnically diverse patients with CKD. Although the original aims of the study were to identify novel predictors of CKD progression and to elucidate the risk and manifestations of cardiovascular disease among nearly 4000 individuals with CKD, the CRIC Study has evolved into a national resource for investigation of a broad spectrumof CKD-related topics. The study has produced >90 published scientific articles, promotedmany young investigative careers in nephrology, and fostered international collaborations focused on understanding the global burden of CKD. The third phase of the CRIC Study will complete enrollment of 1500 additional study participants in 2015 and is designed to answer questions regarding morbidity and mortality in mild-to-moderate CKD and to assess the burden of CKD in older persons. This review highlights some of the salient findings of the CRIC Study in the areas of race and ethnicity, CKD progression, CKD and cognition, and cardiovascular disease outcomes; it also outlines the ongoing and forthcoming opportunities for the global nephrology community to enhance its understanding of CKD and related complications through the study.

Original languageEnglish (US)
Pages (from-to)2073-2083
Number of pages11
JournalClinical Journal of the American Society of Nephrology
Issue number11
StatePublished - Nov 6 2015

ASJC Scopus subject areas

  • Epidemiology
  • Critical Care and Intensive Care Medicine
  • Nephrology
  • Transplantation


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