Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense

Mengfei Chen; Randall R. Reed; Andrew P. Lane

doi:10.1016/j.stem.2019.08.011

Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense

Mengfei Chen, Randall R. Reed, Andrew P. Lane

School of Medicine

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Chen et al. identify the immune function of long-lived olfactory stem cells to regulate inflammatory cell recruitment and local proliferation by releasing cytokines and chemokines. Chronically activated stem cells shut down regenerative function and signal macrophages to maintain epithelial immune defense.

Original language	English (US)
Pages (from-to)	501-513.e5
Journal	Cell stem cell
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2019.08.011
State	Published - Oct 3 2019

Keywords

NF-kB
basal stem cell
chemokine
chronic inflammation
neural stem cell
neurogenesis
olfactory epithelium
regeneration

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

Access to Document

10.1016/j.stem.2019.08.011

Cite this

@article{94355f66be5849469a5d9855cfec4761,

title = "Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense",

abstract = "Chen et al. identify the immune function of long-lived olfactory stem cells to regulate inflammatory cell recruitment and local proliferation by releasing cytokines and chemokines. Chronically activated stem cells shut down regenerative function and signal macrophages to maintain epithelial immune defense.",

keywords = "NF-kB, basal stem cell, chemokine, chronic inflammation, neural stem cell, neurogenesis, olfactory epithelium, regeneration",

author = "Mengfei Chen and Reed, {Randall R.} and Lane, {Andrew P.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

day = "3",

doi = "10.1016/j.stem.2019.08.011",

language = "English (US)",

volume = "25",

pages = "501--513.e5",

journal = "Cell stem cell",

issn = "1934-5909",

publisher = "Cell Press",

number = "4",

}

TY - JOUR

T1 - Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense

AU - Chen, Mengfei

AU - Reed, Randall R.

AU - Lane, Andrew P.

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Chen et al. identify the immune function of long-lived olfactory stem cells to regulate inflammatory cell recruitment and local proliferation by releasing cytokines and chemokines. Chronically activated stem cells shut down regenerative function and signal macrophages to maintain epithelial immune defense.

AB - Chen et al. identify the immune function of long-lived olfactory stem cells to regulate inflammatory cell recruitment and local proliferation by releasing cytokines and chemokines. Chronically activated stem cells shut down regenerative function and signal macrophages to maintain epithelial immune defense.

KW - NF-kB

KW - basal stem cell

KW - chemokine

KW - chronic inflammation

KW - neural stem cell

KW - neurogenesis

KW - olfactory epithelium

KW - regeneration

UR - http://www.scopus.com/inward/record.url?scp=85072718019&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072718019&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2019.08.011

DO - 10.1016/j.stem.2019.08.011

M3 - Article

C2 - 31523027

AN - SCOPUS:85072718019

SN - 1934-5909

VL - 25

SP - 501-513.e5

JO - Cell stem cell

JF - Cell stem cell

IS - 4

ER -

Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this