Chronic Human Glaucoma Causing Selectively Greater Loss of Large Optic Nerve Fibers

Harry A. Quigley; Gregory R. Dunkelberger; W. Richard Green

doi:10.1016/S0161-6420(88)33176-3

Chronic Human Glaucoma Causing Selectively Greater Loss of Large Optic Nerve Fibers

Harry A. Quigley, Gregory R. Dunkelberger, W. Richard Green

School of Medicine

Research output: Contribution to journal › Article › peer-review

446 Scopus citations

Abstract

Eighteen eyes of 12 persons with chronically elevated intraocular pressure (IOP) were studied histologically to determine the number and diameter of optic nerve fibers. In some eyes, automated perimetry had been performed. Optic nerve fibers larger than the mean diameter were killed more rapidly than smaller fibers, although no fiber size was completely spared at any stage of atrophy. The number of optic nerve fibers varies considerably among normal eyes. The authors confirmed that the death of a substantial proportion of optic nerve fibers precedes detectable visual field loss.

Original language	English (US)
Pages (from-to)	357-363
Number of pages	7
Journal	Ophthalmology
Volume	95
Issue number	3
DOIs	https://doi.org/10.1016/S0161-6420(88)33176-3
State	Published - 1988

Keywords

glaucoma
histology
optic nerve
retinal ganglion cells

ASJC Scopus subject areas

Ophthalmology

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10.1016/S0161-6420(88)33176-3

Cite this

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title = "Chronic Human Glaucoma Causing Selectively Greater Loss of Large Optic Nerve Fibers",

abstract = "Eighteen eyes of 12 persons with chronically elevated intraocular pressure (IOP) were studied histologically to determine the number and diameter of optic nerve fibers. In some eyes, automated perimetry had been performed. Optic nerve fibers larger than the mean diameter were killed more rapidly than smaller fibers, although no fiber size was completely spared at any stage of atrophy. The number of optic nerve fibers varies considerably among normal eyes. The authors confirmed that the death of a substantial proportion of optic nerve fibers precedes detectable visual field loss.",

keywords = "glaucoma, histology, optic nerve, retinal ganglion cells",

author = "Quigley, {Harry A.} and Dunkelberger, {Gregory R.} and Green, {W. Richard}",

note = "Funding Information: Supported in part by PHS research grants EY 02120 (Dr. Quigley), EY 01765 (core facility grant, Wilmer Institute), and EY 06888 (principal investigator, Janice Jerdan, PhD) from the National Eye Institute, National Institutes of Health, and by unrestricted funds from National Glaucoma Research, American Health Assistance Foundation, Washington, DC, and the H. Charles Greene Foundation, Inc, Baltimore, Maryland.",

year = "1988",

doi = "10.1016/S0161-6420(88)33176-3",

language = "English (US)",

volume = "95",

pages = "357--363",

journal = "Ophthalmology",

issn = "0161-6420",

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T1 - Chronic Human Glaucoma Causing Selectively Greater Loss of Large Optic Nerve Fibers

AU - Quigley, Harry A.

AU - Dunkelberger, Gregory R.

AU - Green, W. Richard

N1 - Funding Information: Supported in part by PHS research grants EY 02120 (Dr. Quigley), EY 01765 (core facility grant, Wilmer Institute), and EY 06888 (principal investigator, Janice Jerdan, PhD) from the National Eye Institute, National Institutes of Health, and by unrestricted funds from National Glaucoma Research, American Health Assistance Foundation, Washington, DC, and the H. Charles Greene Foundation, Inc, Baltimore, Maryland.

PY - 1988

Y1 - 1988

N2 - Eighteen eyes of 12 persons with chronically elevated intraocular pressure (IOP) were studied histologically to determine the number and diameter of optic nerve fibers. In some eyes, automated perimetry had been performed. Optic nerve fibers larger than the mean diameter were killed more rapidly than smaller fibers, although no fiber size was completely spared at any stage of atrophy. The number of optic nerve fibers varies considerably among normal eyes. The authors confirmed that the death of a substantial proportion of optic nerve fibers precedes detectable visual field loss.

AB - Eighteen eyes of 12 persons with chronically elevated intraocular pressure (IOP) were studied histologically to determine the number and diameter of optic nerve fibers. In some eyes, automated perimetry had been performed. Optic nerve fibers larger than the mean diameter were killed more rapidly than smaller fibers, although no fiber size was completely spared at any stage of atrophy. The number of optic nerve fibers varies considerably among normal eyes. The authors confirmed that the death of a substantial proportion of optic nerve fibers precedes detectable visual field loss.

KW - glaucoma

KW - histology

KW - optic nerve

KW - retinal ganglion cells

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JO - Ophthalmology

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Chronic Human Glaucoma Causing Selectively Greater Loss of Large Optic Nerve Fibers

Abstract

Keywords

ASJC Scopus subject areas

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