Chronic Granulomatous Disease

Jennifer W. Leiding; Steven M. Holland

doi:10.1016/B978-0-12-405546-9.00031-5

Chronic Granulomatous Disease

Jennifer W. Leiding
, Steven M. Holland

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in the structural subunits of the NADPH oxidase. Impaired NADPH oxidase function leads to a narrow spectrum of bacterial and fungal infections. In addition to infection susceptibility, hyperinflammatory disorders such as chronic colitis are a major source of morbidity in CGD patients. Treatment includes antimicrobial prophylaxis and aggressive treatment of infections. Curative therapy is with hematopoietic stem cell transplant.

Original language	English (US)
Title of host publication	Stiehm's Immune Deficiencies
Publisher	Elsevier Inc.
Pages	633-648
Number of pages	16
ISBN (Electronic)	9780124058606
ISBN (Print)	9780124055469
DOIs	https://doi.org/10.1016/B978-0-12-405546-9.00031-5
State	Published - Aug 12 2014
Externally published	Yes

Keywords

CGD
Granuloma
Immunodeficiency
Inflammation

ASJC Scopus subject areas

General Medicine
General Immunology and Microbiology

Access to Document

10.1016/B978-0-12-405546-9.00031-5

Cite this

@inbook{ec6ac325bc78477393e30cb5bd161295,

title = "Chronic Granulomatous Disease",

abstract = "Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in the structural subunits of the NADPH oxidase. Impaired NADPH oxidase function leads to a narrow spectrum of bacterial and fungal infections. In addition to infection susceptibility, hyperinflammatory disorders such as chronic colitis are a major source of morbidity in CGD patients. Treatment includes antimicrobial prophylaxis and aggressive treatment of infections. Curative therapy is with hematopoietic stem cell transplant.",

keywords = "CGD, Granuloma, Immunodeficiency, Inflammation",

author = "Leiding, \{Jennifer W.\} and Holland, \{Steven M.\}",

year = "2014",

month = aug,

day = "12",

doi = "10.1016/B978-0-12-405546-9.00031-5",

language = "English (US)",

isbn = "9780124055469",

pages = "633--648",

booktitle = "Stiehm's Immune Deficiencies",

publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Chronic Granulomatous Disease

AU - Leiding, Jennifer W.

AU - Holland, Steven M.

PY - 2014/8/12

Y1 - 2014/8/12

N2 - Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in the structural subunits of the NADPH oxidase. Impaired NADPH oxidase function leads to a narrow spectrum of bacterial and fungal infections. In addition to infection susceptibility, hyperinflammatory disorders such as chronic colitis are a major source of morbidity in CGD patients. Treatment includes antimicrobial prophylaxis and aggressive treatment of infections. Curative therapy is with hematopoietic stem cell transplant.

AB - Chronic granulomatous disease (CGD) is a primary immunodeficiency caused by defects in the structural subunits of the NADPH oxidase. Impaired NADPH oxidase function leads to a narrow spectrum of bacterial and fungal infections. In addition to infection susceptibility, hyperinflammatory disorders such as chronic colitis are a major source of morbidity in CGD patients. Treatment includes antimicrobial prophylaxis and aggressive treatment of infections. Curative therapy is with hematopoietic stem cell transplant.

KW - CGD

KW - Granuloma

KW - Immunodeficiency

KW - Inflammation

UR - https://www.scopus.com/pages/publications/84943423687

UR - https://www.scopus.com/pages/publications/84943423687#tab=citedBy

U2 - 10.1016/B978-0-12-405546-9.00031-5

DO - 10.1016/B978-0-12-405546-9.00031-5

M3 - Chapter

AN - SCOPUS:84943423687

SN - 9780124055469

SP - 633

EP - 648

BT - Stiehm's Immune Deficiencies

PB - Elsevier Inc.

ER -

Chronic Granulomatous Disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this