Chronic graft-versus-host disease

Stephanie J. Lee, Georgia Vogelsang, Mary E.D. Flowers

Research output: Contribution to journalArticlepeer-review

599 Scopus citations


Chronic graft-versus-host disease (GVHD) remains a vexing and dangerous complication of allogeneic stem cell transplantation. Mild forms of chronic GVHD are often manageable with local or low-dose systemic immunosuppression and do not affect long-term survival. In contrast, more severe forms of chronic GVHD require intensive medical management and adversely affect survival. This report reviews current concepts of the pathogenesis, clinical risk factors, classification systems, organ manifestations, and available treatments for chronic GVHD. It also provides a comprehensive listing of the published clinical trials aimed at prevention and primary treatment of chronic GVHD.

Original languageEnglish (US)
Pages (from-to)215-233
Number of pages19
JournalBiology of Blood and Marrow Transplantation
Issue number4
StatePublished - Apr 2003


  • Allogeneic stem cell transplantation
  • Chronic graft-versus-host disease

ASJC Scopus subject areas

  • Hematology
  • Transplantation


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