Chronic demyelinating polyneuropathy in systemic lupus erythematosus

Emanuel Rechthand, David R. Cornblath, Barney J. Stern, John O. Meyerhoff

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Mononeuritis multiplex and acute demyelinating polyneuropathy (Guillain-Barré syndrome) are well known in systemic lupus erythematosus (SLE). Chronic acquired demyelinating polyneuropathy has been reported rarely in SLE. Two young women had monophasic progressive limb weakness, areflexia, elevated CSF protein, and slow nerve conduction velocities as the first manifestation of SLE. Sural nerve biopsy in one patient revealed mild loss of myelinated fibers and an increased number of thinly myelinated fibers. Steroid therapy led to improvement in both patients. These patients demonstrate that chronic demyelinating polyneuropathy can be an unusual presentation of SLE, even preceding characteristic systemic disease by months.

Original languageEnglish (US)
Pages (from-to)1375-1377
Number of pages3
Issue number10
StatePublished - Oct 1984

ASJC Scopus subject areas

  • Clinical Neurology


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