Chronic cadmium intake results in dose-related excretion of metallothionein in urine

Z. A. Shaikh; K. M. Harnett; S. A. Perlin; P. C. Huang

doi:10.1007/BF01954852

Chronic cadmium intake results in dose-related excretion of metallothionein in urine

Z. A. Shaikh, K. M. Harnett, S. A. Perlin, P. C. Huang

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Urinary excretion of metallothionein was measured by radioimmunoassay in rats given drinking water containing 5 or 50 mg cadmium/1 for up to 2 years. The metallothionein levels corresponded to the concentration of cadmium in the drinking water and increased linearly over the course of the study. These results demonstrate that urinary metallothionein is a sensitive biological indicator of oral cadmium exposure.

Original language	English (US)
Pages (from-to)	146-148
Number of pages	3
Journal	Experientia
Volume	45
Issue number	2
DOIs	https://doi.org/10.1007/BF01954852
State	Published - Feb 1989

Keywords

Cadmium
chronic exposure
metallothionein
urinalysis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/BF01954852

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abstract = "Urinary excretion of metallothionein was measured by radioimmunoassay in rats given drinking water containing 5 or 50 mg cadmium/1 for up to 2 years. The metallothionein levels corresponded to the concentration of cadmium in the drinking water and increased linearly over the course of the study. These results demonstrate that urinary metallothionein is a sensitive biological indicator of oral cadmium exposure.",

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AU - Perlin, S. A.

AU - Huang, P. C.

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AB - Urinary excretion of metallothionein was measured by radioimmunoassay in rats given drinking water containing 5 or 50 mg cadmium/1 for up to 2 years. The metallothionein levels corresponded to the concentration of cadmium in the drinking water and increased linearly over the course of the study. These results demonstrate that urinary metallothionein is a sensitive biological indicator of oral cadmium exposure.

KW - Cadmium

KW - chronic exposure

KW - metallothionein

KW - urinalysis

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Chronic cadmium intake results in dose-related excretion of metallothionein in urine

Abstract

Keywords

ASJC Scopus subject areas

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