Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex

William F. Byerley; Elizabeth J. McConnel; R. Tyler McCabe; Ted M. Dawson; Bernard I. Grosser; James K. Wamsley

doi:10.1016/0006-8993(87)91312-6

Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex

William F. Byerley, Elizabeth J. McConnel, R. Tyler McCabe, Ted M. Dawson, Bernard I. Grosser, James K. Wamsley

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [³H]dihydroalplrenolol ([³H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of β-adrenergic receptors.

Original language	English (US)
Pages (from-to)	377-381
Number of pages	5
Journal	Brain research
Volume	421
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(87)91312-6
State	Published - Sep 22 1987
Externally published	Yes

Keywords

In vitro receptor autoradiography
Serotonin
Sertraline
[H]Dihydroalprenolol
β-Adrenergic

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(87)91312-6

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title = "Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex",

abstract = "Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalplrenolol ([3H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of β-adrenergic receptors.",

keywords = "In vitro receptor autoradiography, Serotonin, Sertraline, [H]Dihydroalprenolol, β-Adrenergic",

author = "Byerley, {William F.} and McConnel, {Elizabeth J.} and {Tyler McCabe}, R. and Dawson, {Ted M.} and Grosser, {Bernard I.} and Wamsley, {James K.}",

note = "Funding Information: We thank Adela Sussman for typing the manuscript. Sertraline was a gift from Pfizer. This work was supported in part by funds from the Department of Psychiatry and from Pfizer, Groton, CT.",

year = "1987",

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doi = "10.1016/0006-8993(87)91312-6",

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pages = "377--381",

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T1 - Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex

AU - Byerley, William F.

AU - McConnel, Elizabeth J.

AU - Tyler McCabe, R.

AU - Dawson, Ted M.

AU - Grosser, Bernard I.

AU - Wamsley, James K.

N1 - Funding Information: We thank Adela Sussman for typing the manuscript. Sertraline was a gift from Pfizer. This work was supported in part by funds from the Department of Psychiatry and from Pfizer, Groton, CT.

PY - 1987/9/22

Y1 - 1987/9/22

N2 - Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalplrenolol ([3H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of β-adrenergic receptors.

AB - Sertraline, a potent and selective inhibitor of serotonin uptake, was chronically administered to laboratory rats. Using in vitro receptor autoradiographic techniques, we found that the binding of [3H]dihydroalplrenolol ([3H]DHA) was reduced in cortex layers IV-VI. Results of a saturation experiment indicated that the reduction in cortex layer IV was due to a change in number but not affinity of β-adrenergic receptors.

KW - In vitro receptor autoradiography

KW - Serotonin

KW - Sertraline

KW - [H]Dihydroalprenolol

KW - β-Adrenergic

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Chronic administration of sertraline, a selective serotonin uptake inhibitor, decreased the density of β-adrenergic receptors in rat frontoparietal cortex

Abstract

Keywords

ASJC Scopus subject areas

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