Chromosome segregation and cancer: Cutting through the mystery

Prasad V. Jallepalli, Christoph Lengauer

Research output: Contribution to journalArticlepeer-review

325 Scopus citations


Mitosis is the most dramatic - and potentially dangerous - event in the cell cycle, as sister chromatids are irreversibly segregated to daughter cells. Defects in the checkpoints that normally maintain the fidelity of this process can lead to chromosomal instability (CIN) and cancer. However, CIN - a driving force of tumorigenesis - could be the cancer cell's ultimate vulnerability. An important goal is to identify novel anticancer compounds that directly target the mitotic errors at the heart of CIN.

Original languageEnglish (US)
Pages (from-to)109-117
Number of pages9
JournalNature Reviews Cancer
Issue number2
StatePublished - 2001

ASJC Scopus subject areas

  • Cancer Research


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