TY - JOUR
T1 - Chromosome-centric human proteome project (C-HPP)
T2 - Chromosome 12
AU - Chaiyarit, Sakdithep
AU - Singhto, Nilubon
AU - Chen, Yi Ju
AU - Cheng, Chia Ying
AU - Chiangjong, Wararat
AU - Kanlaya, Rattiyaporn
AU - Lam, Henry H N
AU - Peerapen, Paleerath
AU - Sung, Ting Yi
AU - Tipthara, Phornpimon
AU - Pandey, Akhilesh
AU - Poon, Terence C W
AU - Chen, Yu Ju
AU - Sirdeshmukh, Ravi
AU - Chung, Maxey C M
AU - Thongboonkerd, Visith
PY - 2014/7/3
Y1 - 2014/7/3
N2 - Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).
AB - Following an official announcement of the Chromosome-centric Human Proteome Project (C-HPP), the Chromosome 12 (Ch12) Consortium has been established by five representative teams from five Asian countries including Thailand (Siriraj Hospital, Mahidol University), Singapore (National University of Singapore), Taiwan (Academia Sinica), Hong Kong (The Chinese University of Hong Kong), and India (Institute of Bioinformatics). We have worked closely together to extensively and systematically analyze all missing and known proteins encoded by Ch12 for their tissue/cellular/subcellular localizations. The target organs/tissues/cells include kidney, brain, gastrointestinal tissues, blood/immune cells, and stem cells. In the later phase, post-translational modifications and functional significance of Ch12-encoded proteins as well as their associations with human diseases (i.e., immune diseases, metabolic disorders, and cancers) will be defined. We have collaborated with other chromosome teams, Human Kidney and Urine Proteome Project (HKUPP), AOHUPO Membrane Proteomics Initiative, and other existing HUPO initiatives in the Biology/Disease-Based Human Proteome Project (B/D-HPP) to delineate functional roles and medical implications of Ch12-encoded proteins. The data set to be obtained from this multicountry consortium will be an important piece of the jigsaw puzzle to fulfill the missions and goals of the C-HPP and the global Human Proteome Project (HPP).
KW - B/D-HPP
KW - C-HPP
KW - chromosome 12
KW - chromosome-centric
KW - HPP
KW - Human Proteome Organization
KW - Human Proteome Project
KW - HUPO
UR - http://www.scopus.com/inward/record.url?scp=84903750474&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903750474&partnerID=8YFLogxK
U2 - 10.1021/pr500009j
DO - 10.1021/pr500009j
M3 - Article
C2 - 24831074
AN - SCOPUS:84903750474
SN - 1535-3893
VL - 13
SP - 3160
EP - 3165
JO - Journal of Proteome Research
JF - Journal of Proteome Research
IS - 7
ER -