Chromobacterium biopesticide overcomes insecticide resistance in malaria vector mosquitoes

Chinmay V. Tikhe, Sare Issiaka, Yuemei Dong, Mary Kefi, Mihra Tavadia, Etienne Bilgo, Rodrigo M. Corder, John Marshall, Abdoulaye Diabate, George Dimopoulos

Research output: Contribution to journalArticlepeer-review

Abstract

Vector mosquito control is an integral part of malaria control. The global emergence of insecticide resistance in malaria-transmitting Anophelines has become an impediment and has created an urgent need for novel mosquito control approaches. Here, we show that a biopesticide derived from the soil-dwelling bacterium Chromobacterium sp. Panama (Csp_P) kills insecticide-resistant Anopheles mosquitoes, regardless of their resistance mechanisms. In addition, sublethal dose of Csp_P acts as a synergist to now used chemical insecticides across multiple classes. Moreover, Csp_P reduces host-seeking behavior and malaria parasite infection in vector mosquitoes in ways that further decrease transmission. Mosquito glutathione S-transferases are essential for Csp_P’s mosquito-killing mechanism. Enclosed field trials in Burkina Faso, conducted in diverse ecological settings and supported by a mathematical model, have now demonstrated its potential for malaria control in settings with widespread insecticide resistance.

Original languageEnglish (US)
Article numbereads3658
JournalScience Advances
Volume10
Issue number49
DOIs
StatePublished - Dec 6 2024

ASJC Scopus subject areas

  • General

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