Chromium(VI) ions induce caspase-3-independent osteoblast cytotoxicity

M. Overstreet, J. Ha, D. Hungerford, C. G. Frondoza

Research output: Chapter in Book/Report/Conference proceedingConference contribution


The cytotoxicity of chromium ions on human osteoblasts were tested in order to determine the involvement of apoptosis. Cells cultured on chamber slides were incubated with ions for 24 hours and treated with Hoechst stain to visualize the nucleus. Cr 3+ was found to have effect on the DNA synthesis rates whereas Cr 6+ decreased DNA synthesis rates in a dose dependent manner. It was also found that Cr 6+ ions induces dose-dependent osteoblast toxicity without activation of the caspase-3 enzyme.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Number of pages1
StatePublished - Dec 1 2004
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Publication series

NameTransactions - 7th World Biomaterials Congress


OtherTransactions - 7th World Biomaterials Congress

ASJC Scopus subject areas

  • Engineering(all)


Dive into the research topics of 'Chromium(VI) ions induce caspase-3-independent osteoblast cytotoxicity'. Together they form a unique fingerprint.

Cite this