Chromium 51 cytotoxicity crossmatch monitoring cellular and humoral immunity in renal transplantation

S. Sterioff, J. R. Wunderlich, G. M. Williams

Research output: Contribution to journalArticlepeer-review

Abstract

The findings suggest that cellular immunity to donor antigens can be monitored by a 14 hr in vitro assay prior to transplantation; the exclusion of cellular as well as humoral immunity to donor antigens may be important in reducing the frequency of hyperacute and early fulminating transplant rejection; and serum factors blocking or augmenting lymphocyte kill may be evaluated with the 51Cr release technique. Absence of detectable cellular and humoral immunity in the primary one haplotype identical transplant cited above, before and after fulminating rejection implies the following: All early and violent graft rejections may not be attributed to presensitization, but may involve the individual recipient's ability to initiate and sustain a severe primary rejection response. The lymphocyte target cell as representative of donor tissue antigens may not be a perfect proxy for renal cells; And peripheral blood lymphocytes may not be competent effector cells at any given time, depending upon the general immune status of the patient.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalSurgical forum
VolumeVol. 23
StatePublished - Jan 1 1972

ASJC Scopus subject areas

  • Surgery

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